Lipohyalinosis is small vessel disease in the brain. Hypertension is a strong causative factor. So called deep perforating arteries, relatively small arteries branching of from relatively large arteries are especially prone [1]. Normally the tension drops as arteries split into smaller and smaller arteries, but because the small perforating arteries branch directly from larger arteries, they are under relatively large pressure.
It can lead to lacunar infarcts, a type of stroke. Currently microatheroma is considered the most important cause, though.
Chronic familial lipohyalinosis is a rare inherited variant.
References
- ^ Brenner D, Labreuche J, Pico F, et al. The renin-angiotensin-aldosterone system in cerebral small vessel disease. J Neurol. May 2 2000
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