MacIsaac is a surname and may refer to:
- Angus MacIsaac (born 1943), English educator and businessman
- Angus MacIsaac (footballer)
- Ashley MacIsaac (born 1975), Canadian fiddler
- Dave MacIsaac (born 1955), Canadian musician
- Martha MacIsaac (born 1984), Canadian actress
- Mary MacIsaac (1893 – 2006), Saskatchewan's oldest person
- Rob MacIsaac (born 1962), Canadian politician
| This page or section lists people with the surname MacIsaac. If an internal link intending to refer to a specific person led you to this page, you may wish to change that link by adding the person's given name(s) to the link. |
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