O'Brian may refer to:
People named O'Brian
- Hugh O'Brian (born 1925), U.S. actor
- Jack O'Brian, (1914–2000), columnist and supporter of Joseph McCarthy
- Patrick O'Brian (1914–2000), British novelist and translator
- Peter O'Brian (born 1947), Canadian film producer
Fictional people named O'Brian
- Chloe O'Brian, a character in the American TV series 24
- Morris O'Brian, a character in the American TV series 24
See also
- O'Brien, similarly spelled surname
- Dara Ó Briain, Irish comedian and presenter
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