| Phosphoribosyl pyrophosphate | |
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| Properties | |
| Molecular formula | C5H13O14P3 |
| Molar mass | 390.07 g/mol |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) | |
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Phosphoribosyl pyrophosphate (PRPP) is a pentosephosphate.
It is formed from ribose 5-phosphate by the enzyme ribose-phosphate diphosphokinase.
It plays a role in transferring phospho-ribose groups in several reactions:
| Enzyme | Reactant | Product |
|---|---|---|
| adenine phosphoribosyltransferase | adenine | AMP |
| hypoxanthine-guanine phosphoribosyltransferase | guanine | GMP |
| hypoxanthine-guanine phosphoribosyltransferase | hypoxanthine | IMP |
| orotate phosphoribosyltransferase | orotate | OMP |
| uracil phosphoribosyltransferase | uracil | UMP |
In de novo generation of purines, the enzyme amidophosphoribosyltransferase acts upon PRPP to create phosphoribosylamine.
See also
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