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No. The .22 LR is a straight sided RIMFIRE cartridge. The Hornet is a bottlenecked CENTERFIRE cartridge. The chamber of a Hornet is MUCH bigger- you could not get a Hornet into a .22 LR chamber- and the firing pin would hit in the wrong place.
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Earn +20 ptsQ: Can a 22 long rifle pistol shoot the 22 hornet ammo?
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