Can Benadryl cause liver damage?

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Yes, Benadryl (diphenhydramine) is extensively metabolized by the liver. With abuse or overdose of diphenhydramine, liver damage can (and likely will) occur. There are also other side effects such as cardiac collapse. It is best to only take any medication exactly as directed. If you are taking any over the counter medication for an extended period of time, you need to consult with your doctor.
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