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Yes.

Omeprazole (Prilosec) does not interfere with either the triptan medications or over the counter marketed pain relievers such as Excedrin/Excedrin Migraine.

In fact, when omeprazole is taken with aspirin (which is found in Excedrin) it has been shown to protect against the potential for creating ulcers.

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Q: Can migraine relief tablets be taken at the same time as omeprazole?
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