Yes.
MapQuest gives the estimated driving time as 15 hours and 42 minutes.
Yes, it is possible to drive to Key West Florida. Although it doesn't look like it from a map, there are multiple bridges/land bridges that will take you all the way down to the tips of the keys - Key West.
It is a 26 hour drive to Key West, FLorida.
About 3 hours and 48 minutes.
The driving distance from Seattle to Key West is about 3,454 miles.
Orlando to Key WestThe distance from Orlando, Florida to Key West, Florida is 438 Kilometers or 272 Miles.This would take you approximately 6 and a half hours to drive.
There is approximately 372 miles between Sarasota, Florida and Key West, Florida. It would about 7 hours to drive in a car.
Palm Coast to Key West is 446.61 miles and would take 7 hours and 34 minutes to drive. [Source: Mapquest]
It would take approximately 3 and a half hours to drive from Miami, Florida to Key West, Florida. Miami is 160 miles north of Key West.
You can fly to the airport or drive the US-1.
Fort Lauderdale to Key West is 189.26 miles and would take 3 hours and 42 minutes to drive. [Source: Mapquest]
It is 231 miles long and exciting if you enjoy driving over water.