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This is a Antihistimine, used for the SHORT TERM relief of hay fever +respiratory Allergies.Yes you can overdose.You can get very drowsy,especially if taken with any alcohol, do not drive etc,etc. They are used in some nightime sleep aids for insomnia so for overdosing, yes you can.....You can overdose on anything. Too much water, too much oxygen, too much alcohol, etc... Everything in moderation. Unless it's bad for you to begin with then forget moderation, don't do it.

Some people take it in high doses as a recreational drug, but it's highly unpopular because the trip, well, sucks. It is usually is made up of a complete loss of short-term memory, an uncomfortable body high, and rather horrifying, extremely realistic hallucinations. The most common hallucination is a massive amounts of large, hairy Spiders crawling over everything, including you, which persists throughout the entire ~6-hour trip. Its fairly safe in terms of health, but if you attempt to defend yourself with a hunting knife against that rabid wolverine only to find it to be your cat, you'll probably regret it.

Doses for this range from 300mg to around 1500mg usually without any real hazardous side effects, but on user reported taking 2000mg and surviving but ended up in the hospital.

Just stick with normal doses and there's no worries.

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13y ago
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9y ago

Yes, you can. The fatal range is usually stated around 20 - 40 mg per kg of body weight. However, most people who overdose with the intent of suicide do not die. For example, from 1985 to 2002, out of 28,092 diphenhydramine overdoses reported to TESS, only 48 deaths resulted from ingesting only diphenhydramine.

Permanent damage from overdoses does not usually occur, but overdoses can be very unpleasant due to diphenhydramine's anticholinergic effects. Also, the effects at various dosages vary from person to person, with higher dosages generally causing more negative symptoms. A dosage that feels good to one person may make another person miserable (which is very common). But pretty much everyone feels awful on a toxic or lethal overdose.

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14y ago

Addicted... no, not in the physical sense like you can with alcohol, tobacco, heroin, etc.

You can become psychologically addicted and dependent on pretty much anything though, including diphenhydramine.

My sister claims to be addicted to them for getting to sleep where in actual fact its closer to say she is a habitual user.

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12y ago

Diphenhydramine (Benadryl) is available over the counter, and has very few side effects. There is no black market in it. And it's checmically distinct from most drugs on a standard drug screen. So no -- it will not light up a positive on any normal, properly conducted, drug test.

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12y ago

Yes, you can overdose on any drug even vitamins.

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14y ago

Possibly, but it would really mess up your lungs by causing the membranes to dry out. Don't try it unless you like hospitals.

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9y ago

You can become addicted to Benadryl or any other medication that makes you feel better or relieves your symptoms.

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Q: Can you overdose on diphenhydramine hydrochloride?
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Chemical formula for diphenhydramine hydrochloride?

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I took a drug test in the hospital and they didn't even find it when i took 1000mg of diphenhydramine hydrochloride the night before.


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You would probably get an overdose of antihistamine, would not recommend it.


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What is the difference between Cetirizine hydrochloride and Cetirizine dihydrochloride?

The active ingredient in both pills is the same (Cetirizine). The difference between hydrochloride and dihydrochloride is the difference between the non active ingredients in the pills that are added to the drug so that there is enough bulk to make a pill. The above 'advice' is simply rubbish. Any (old Skool) A-Level chemistry student knows the difference between 'hydrochloride' and 'di-hydrochloride': Not the same molecule.However, in layman's terms: cetirizine di-hydrochloride is the real thing and is less likely to make you drowsy. Cetirizine hydrochloride is a copycat molecule to work around patent laws.From personal experience, cetirizine hydrochloride makes me drowsy, whereas cetirizine di-hydrochloride does not. :-)


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