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Can you reduce amperage by using thicker wire with a constant voltage?

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The amperage flowing through a wire is directly related to the load placed on the circuit, and has nothing to do with wire size, except that a larger wire will carry more amperage. Increasing wire size will not lower amperage but will allow the circuit to carry more amperage if the breaker is also increased in size.  
No. Ohm's law tells us that V = IR. For a given load, R is constant, and thus the only way to reduce current is to increase voltage.
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