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n nHexokinase: Its function is to make sure there is enough glc for the tissues, even in the presence of low blood glc concentrations, by phosphorylating all the glc concentration gradient between the blood and the intracellular environment.
n nGlucokinase: Its function is to remove glc from the blood following a meal. n n(Hexokinase, Phosphofructokinase and pyruvate kinase, are 3 regulatory enzymes of glycolysis.) nLiver has an additional enzyme, glucokinase, that phosphorylate only glc
n n1. Glucokinase has a high Km because it phosphorylates glc only when its concentration is high. This occurs during the brief period after consumption of a carbohydrate rich meal, when high glc are delivered by portal vein.
n n2. Glucokinase has a high Vmax, allowing the liver to remove effectively this flood of glc from the portal blood. So this prevents extreme hyperglycemia after meals.
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What enzyme is responsible for aerobic respiration?
There are very many enzymes involved. A few from glycolysis are: hexokinase and glucokinase, phosphohexose isomerase, phosphofructokinase, pyruvate kinase; from pyruvate decarboxylation are pyruvate dehydrogenase phosphatase and pyruvate dehydrogenase kinase; and a few from the Kreb's cycle are: aconitase, alpha-ketoglutamate dehydrogenase, succinate thiokinase, and fumarase.
What enzyme phosphorylates 90% of the glucose in the liver?
glucokinase
How does hexokinase maintain homeostasis?
it doesnt
What is a function of enzyme protein for example hexokinase?
Hexokinase is an enzyme involved in the phosphorylation of hexose (five carbon sugar). It speeds the process on adding a phosphorus to the sugar.
What are example of enzymes regulated by feed back?
Glucokinase is the enzyme responsible for phosphorylation of glucose in the first step of glycolysis. The glucokinase complex is modified by two different molecules: citrate and ATP. Citrate and ATP are both products of the sequence of reactions in aerobic respiration and are consequently products of glycolysis. As these two molecules' concentrations in the cell build up, they bind to the allosteric site of glucokinase and shut it down.
Which has a higher Vmax: glucokinase or hexokinase?
Glucokinase
Which has a higher affinity for glucose: hexokinase or glucokinase?
Hexokinase
Which of the following is characteristic of hexokinase (as opposed to glucokinase)?
It is not inducible by insulin
What substrate is converted into glucose 6 phosphate by the enzyme hexokinase?
Glucose, although only the liver uses a different enzyme, called glucokinase which does the same thing.
Why is glucokinase inactive in the nucleus?
Glucokinase Regulatory Protein is found in the nucleus which binds glucokinase to inactive it
What is hexokinase?
a hexokinase is an enzyme that catalyzes the phosphorylation of hexoses.
where is glucokinase active intracellularly?
in the cytosol
What is the glucose sensor in B-cells Why?
glucokinase. glucokinase has a high km(low affinity for glucose) so glucokinase only phosphorylates glucose when blood glucose is high, such as after a meal. As such, it makes sense that this would be sensor for B-cells
What enzyme is responsible for aerobic respiration?
There are very many enzymes involved. A few from glycolysis are: hexokinase and glucokinase, phosphohexose isomerase, phosphofructokinase, pyruvate kinase; from pyruvate decarboxylation are pyruvate dehydrogenase phosphatase and pyruvate dehydrogenase kinase; and a few from the Kreb's cycle are: aconitase, alpha-ketoglutamate dehydrogenase, succinate thiokinase, and fumarase.
How does ATP inhibit hexokinase?
No it is not!
What enzyme catalyze the phosphorylation of glucose after a meal?
glucokinase
What happens if you have a glucokinase deficiency?
You can't produce insulin
