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I have taken Depakote for almost 9 years with no side affects other some sunlight sensitivity after first starting to take the drug for bipolar manic-depression treatment. Depakote can affect the liver. A blood test for checking liver function is usually recommended. Talk to your doctor or pharamacist if you have any side affect concerns.

the only skin affected side effects are: Rash, alopceia(hair loss), sensitvity to sun, and dry skin. this drug may also make you more prone to buising also according to my nursing drug handbook

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Q: Does Depakote have any side effects on the skin such as dark pigmentation spots on the face or sensitivity to the sun?
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