IL-6 is relevant to many disease processes such as diabetes, atherosclerosis, systemic lupus erythematosus, prostate cancer, and rheumatoid arthritis. Advanced/metastatic cancer patients have higher levels of IL-6 in their blood.Hence there is an interest in developing anti-IL-6 agents as therapy against many of these diseases. The first such is tocilizumab which has been approved for rheumatoid arthritis. Another, ALD518, is in clinical trials.

Tocilizumab (INN, or atlizumab, developed by Hoffmann-La Roche and Chugai under the trade names Actemra and RoActemra) is a humanized monoclonal antibody against the interleukin-6 receptor (IL-6R) used as an immunosuppressive drug, mainly for the treatment of rheumatoid arthritis. Interleukin 6 is a cytokine that plays an important role in immune response and is implicated in the pathogenesis of many diseases, such as autoimmune diseases, multiple myeloma and prostate cancer.

(Source wikipedia)

Rheumatoid arthritis is a chronic autoimmune disease and is best recognized for the damage it does to the joints of the body By its destruction of cartilage and the deformation of the joints and areas surrounding them. However Ra inflammation can effect many other part in the body

RA-related inflammation of the blood vessels, or vasculitis, can cause changes to the skin and surrounding tissue that can appear as ulcers.

Other types of rashes or skin changes related to RA or medications may be seen in patients. It's important to alert your doctor regarding any skin rash or sores.

Having rheumatoid arthritis also puts you at risk of Sjogren's syndrome, a condition in which the immune system attacks the lacrimal glands, which produce tears. This can cause your eyes to feel gritty and dry. If not treated, dryness can lead to infection and scarring of the conjunctiva (the membrane that covers the eye) and cornea. If you have rheumatoid arthritis, ask your doctor about the need for regular eye exams.

What is juvenile rheumatoid arthritis

Arthritis that occurs in people under the age of 16 is referred to as juvenile arthritis. "Juvenile arthritis" covers a number of different types of arthritis in children. The most prevalent type is called "juvenile idiopathic arthritis" or JIA, and also called "juvenile rheumatoid arthritis" (JRA) or "juvenile chronic arthritis" (JCA). A child can be struck by this disease at any age from babies onwards. It may present with only mild symptoms or it may start with a severe full blown attack. Many children, while suffering some discomfort and pain from this disease, are able to get on with normal lives. However, for others it can be a very debilitating condition accompanied by pain and limited mobility in everyday activities. As there is still no cure for juvenile arthritis we can only treat the symptoms in an effort to limit pain and damage to joints and other tissue. For some children the symptoms of arthritis may disappear for a time, or the arthritis may even go into remission entirely. Others will continue to have arthritis into their adult years.

About 250,000 children are said to have JRA in the USA.

Arthritis Arthritis is a very painful chronic illness. I should know, I am a thirteen year old who has had it since the age of eight. It causes joint pains. There is no way to tell if you can outgrow it. It usually stays for the rest of your life.

For more information, contact the Arthritis Foundation or visit their website: arthritis.org

Also here is a article of a older brother's story of what happens when a younger brother gets arthritis: URL moved to discusion section

Degenerative joint disease or osteoarthritis is a form of arthritis that is the result of wear and tear leading to the breakdown of cartilage in joints and damage to bones in joints. it is the most common form of joint disease. Rheumatoid arthritis is an autoimmune disease that affects mainly joints but may also have an effect on many other tissues of the body. Rheumatoid arthritis is the result of the immune system mistakenly attacking the body's own tissues leading to serous damage if left untreated.

Vision can can be effected as a result of a number of problems associated with rheumatoid arthritis.

Scleritis, a chronic inflammation of the blood vessels in the whites of the eyes, may occur in aproximately 1 percent of people with RA. Symptoms include eye pain and redness. If it goes untreated, scleritis may become severe, leading to a deterioration of the cornea.

Rheumatoid Arthritis may lead to Keratoconjunctivitis sicca, which is dryness of the eyes caused by decreased tear production. as well as Episcleritis or scleritis, this is an inflammation of the connective tissue of the eye that gives it a red eye appearance like conjunctivitis, but different as there is no wetness or tearing.

These problems can be painful and lead to increased light sensitivity, redness, and even vision loss.

The eyes may often become dry and/or inflamed as a result of RA. This condition is known as Sjögren syndrome and its severity depends on which part of the eye is affected. this along with many other eye problems may be the result of rheumatoid arthritis and often require the attention of an eye specialist.

Autoantibodies can be prognostic markers of an erosive disease in early rheumatoid arthritis

See the related link below for more info on this subject.

Rheumatoid arthritis is definitely the most harmful condition out of the two diseases. Osteoarthritis is generally associated with wear and tear in the joints and accident it's effects are limited to the joints damage in this case can also extend to pressure being put on nerves that pass between joint, especially between vertebrae with problems occurring in muscles as a result. However Rheumatoid arthritis is a autoimmune disease wherein the immune system attacks cartilage in the joints leading to the destruction of cartilage and the creation of a toxic material that further damages ligaments muscle and bone in the surrounding area. the effect of are not limited to just joints and can also be found in many other organs and tissues of the body such as the heart, lungs, brain, vascular /arterial, eyes skin, etc.

Raised ESR is an indication if inflammation somewhere in the body it does not indicate what the cause of the inflammation is. The trick is to find out what is causing the inflammation and take it from there. For example in the case off rheumatoid arthritis there are a number of different anti inflammatory available both steroidal and non steroidal. as well as disease modifying drugs that inhibit the immune system to be able to inflame.

I am male and have suffered from the symptoms of rheumatoid arthritis since I was less than 10 years old. fortunately It was never so much of a problem in those days as to have warranted a great deal of attention However at about age 40 I did end up having bouts of pain that at times were very intense. My mother had suffered from RA and had developed a philosophical point of view about it and just pressed on. So I did the same, which was a big mistake. My arthritis got progressively worse until when I was about 55 I reached a point where, at times, just getting out of the car had started to become a bit of a challenge. Occasionally I would see a doctor and he would prescribe some non steroidal anti inflammatory and this would settle it down again for a while. However one day one of the people at my work pointed out to me that one of my elbows was badly swollen. I took this to my doctor and as it turned out ended up seeing a different doctor from the usual. to cut a long story short he suspected RA and initiated tests to check this out. In the mean time He put me onto a fairly heavy dose of prednisone which brought the swelling in the elbow and some discomfort and minor swelling in other joints under control. When the results from blood tests and X ray came in they indicated that I had a high Rheumatoid factor accompanied with joint damage to a greater or lesser degree all over my body. (Mind you at this time I was still very active in the construction industry and was often engaged in a very physical capacity. As a result of the outcome of the tests I was referred to a Rheumatologist along with a folder full of joint x rays and test results. After an initial examination He informed me that we would start of by reducing the inflammation by using Prednisone ( Prednisone is a steroidal anti inflammatory that is widely used with inflammatory arthritis) prednisone is usually taken only every morning with food. Also a drug called Methotrexate once a week was prescribed. (Methotrexate is a disease modifying drug that interferes with the ability of the immune system to be able to produce the cells that cause the destructive inflammation that is at the root of RA). Methotrexate needs to be accompanied with folic acid taken daily, to protect you from liver damage. After about 6 month of this the amount of prednisone was reduced gradually until it was down to 5ml per day, ideally no prednisone is best. during the set ling down period I consulted my rheumatologist every 3 months and because I was taking Methotrexate I needed to have a blood test to keep an eye open for liver toxicity at first monthly which has now set led down to 3 monthly, these blood tests also check for inflammation, blood count sometimes RF and a couple of other things that I cant think of right now. In any case everything seemed to be under control except the elbow which was going from bad to worse, Another disease modifying drug was added by the name of Plaquenil to make further modifications to the immune system, however Alas I was too late to save the elbow so at a certain point I was referred to a orthopedic surgeon to have it replaced with a new metal one. That went well even though not quite as good as the real thing as it does have limits on what you can do with it. In any case I am 62 now and have been getting organized treatment for RA for about 6 years. I have to take a few different tablets in the mornings, one at night, and a blood test every 3 months, visit my rheumatologist every 6 months. Because of the drugs I take have to be more careful to stay out of the way of infectious diseases like flu. Believe me even if you did not have a problem with them before you will be far more susceptible to them wit a compromised immune system. Make flu shots part of the treatment. And keep an eye on your overall health as RA can affect many other organs in the body. Medicine can do great things to improve the quality of life However it is important also to maintain your own positive outlook as getting depressed about things that you can not change will cause stress, and emotional stress in my experience is one of the things that causes RA to flare. This is probably why more women suffer from it then men.