How does physical and occupational therapy treat myasthenia gravis?
Physical and occupational therapists provide strategies to maintian daily activities. Shower stools, rolling carts for shopping and exercises to maintain posture all help avoid fatigue.
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Answer . It is an autoimmune neuromuscular disease, characterized by muscle weakness and fatiguability. Where antibodies are directed against the muscle's own acetylcholin…e receptors that stimulates its contraction. Leading to increasing weakness of the body muscles during periods of activity; since the muscle contracts less at every stimulus. MG is a chronic autoimmune neuromuscular disease characterized by degrees of weakness of the skeletal muscles of the body which increases during periods of activity and improves after periods of rest.
Neostigmine is preferred for treatment of myasthenia gravis. Pyridostigmine is longer acting than neostigmine.
these drugs improve the nerve signals to the muscles therefore there will be an increase in the muscle strength.
Initial symptoms of MG may include difficulty speaking (dysarthria), difficulty swallowing (dysphagia), drooping eyelids (ptosis), and double vision (diplopia). Patients often… have nasal-sounding speech and weak neck muscles that give the head a tendency to fall forward or backward.These symptoms occur in about 90% of MG cases, are usually intermittent (i.e., come and go), and may disappear for weeks and then recur. Generalized weakness often develops in the trunk, arms, and legs within a year of onset. Arm muscles usually are affected most severely. Muscle weakness tends to worsen as the day progresses, especially after prolonged activity. Pregnancy can improve, worsen, or have little effect on MG symptoms. Frequently, symptoms first occur during pregnancy or after delivery.
People with MG suffer with debilitating muscle weaknesses in their arms, legs, face, throat, hands and eyes. The symptoms of muscle weakness may occur at any time but most oft…en after normal use of the extremities, i.e. Taking a walk may cause leg weakness and reading a book may cause eye weakness
I've had MG (diagnosed) for 17 years. It would seem that MG could result in gastroparesis. However, it is possible that MG treated with large doses of prednisone or other co…rticosteroids over a long time might be the route. The prednisone causes a challenge to blood sugar control, sometimes leading to diabetes in the MG patient. Diabetes is said to be the leading known cause of gastroparesis. Be very careful weaning off of prednisone; follow a knowledgeable MD's instructions. It is my experience that the AMA physicians can be very helpful with MG, as can naturopaths, accupunturists, etc. when working in cooperation with an MD. None, however, including the MDs, know everything about MG - particularly its expression and course in atypical patients.
Corticosteroids provide significant improvement or complete relief of symptoms in more than 75% of people, and some improvement occurs in most of the rest.
The need for the drug varies from day to day and during the same day in response to infection, menstruation, emotional stress, and hot weather. Different muscles respond diffe…rently.
Immune globulin given intravenously results in improvement in more than half of MG patients, usually beginning within one week of therapy and lasting for several weeks or mont…hs.
Plasma exchange is used as a short-term intervention for patients with sudden worsening of symptoms, to rapidly improve strength before surgery, and as a chronic intermittent …treatment.
Thymectomy or thymus removal is recommended for most with this disease. Greatest benefit occurs 2 to 5 years afterwards. The best response are in young people early in the ons…et.
It takes 6 to 8 weeks of drug therapy to see improvement. About 1/3 of patients become weaker temporarily after starting prednisone, usually in the first 7 to 10 days, but thi…s weakness is temporary.
The most commonly prescribed cholinesterase inhibitors are pyridostigmine bromide (Mestinon) and neostigmine bromide (Prostigmin).
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What are the possible adverse side effects associated with taking cyclosporine to treat myasthenia gravis?
Possible side effects include drug contraindications that interfere with cyclosporine metabolism and life threatening infections are a risk.
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The major disadvantages of chronic corticosteroid therapy are the side effects, such as weight gain and fluid retention.
An occupational therapist can suggest home or work modifications to reduce fatigue and improve function.
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Neostigmine is a competitive irreversible inhibitor ofAcetylcholinesterase (AChE), an enzyme responsible for breakingdown acetylcholine (ACh). Myasthenia gravis is caused by t…he bodyproducing too little ACh receptors. As stimulating the AChreceptors is needed for nervous transmission, the nerve signalscannot be transmitted causing muscle weakness and fatigue.Neostigmine is hence used to inhibit AChE so that less ACh getsbroken down. This leads to more ACh binding to the ACh receptorscausing muscular contraction.