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Depends on how big it is. As a rule you should cook a 5lb meatloaf in a loaf pan for about 1 and a half hours at 325F. Cover with foil unless you put ketchup or catsup on top of it - you can brown it wen it's cooked. Best thing to do is to get a thermometer, once the meatloaf hits 160-165F internally then it should be moist and juicy and cooked. See my blog for the best turkey meatloaf recipe ever and for amazing and original turkey recipes. http://www.loveturkeymeat.info

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15y ago
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14y ago

Never cook for just 22 minutes, even if it's just a 1lb. Cook it on 350 for 40 minutes per lb. 1 lb. of ground beef = 375 degrees for one hour

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9y ago

You should cook a 2 pound turkey meatloaf for about 45 minutes. Depending on the temperature you could cook it for more or less time.

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12y ago

1-1.5 hours

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Q: How long do you cook a turkey meatloaf?
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