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This was a research done by Hans Spemann, an embryologist of the early 20th century in Germany.

His research lead him to conclude that the dorsal and ventral (top and bottom) halves of the embryo were different. The top half contained a certain group of cells that organize development. They are visible on the dorsal surface of a 2-cell-stage embryo.

The outcome of his constriction experiments depended on exactly where this structure was in relation to the constriction. If one half of the constriction contained the entire structure, it would develop into an embryo that could live and the other half developed into the belly-piece.

If the structure was evenly split during the constriction, the result was twin, including Siamese twin, embryos. If it was split unevenly, it resulted (in some cases) an embryo with two heads (a Siamese twin).

He also inadvertently discovered a way to clone during this process of constricting embryos as they split.

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Q: Is it possible to have an uneven split of an embryo?
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