The first major experiment that led the discovery of DNA as the genetic material was performed by Griffith and Avery. They studied 2 strains of bacteria "Streptococcus Pneumonia, which causes pneumonia. They found that one strain could be transformed into other forms of bacteria and germs.
The culmination of experiments proved DNA contains hereditary information. Scientists have known about DNA since the 1860's but it was assumed that protein complexes carries the information for genetic traits. Not until Griffith first recognized a "transformation principle" during his work with viruses was DNA considered to contain hereditary information. Very few biologists however believed from his work alone that DNA contained hereditary information. The Avery-MacLeod-McCarty experiment, a continuation of the Griffith experiment, proved DNA, not proteins, are responsible for trait retention in offspring. Later Hershey and Chase took a radical approach with radio-tagging phosphorous and sulfur molecules in viruses to determine which of the two were passed on to offspring. Their experiment confirmed the conclusion of the Griffith and Avery-MacLeod-McCarty experiment, DNA contains hereditary information.
The result was that it changed scientists opinions on how traits were inherited. Scientists originally thought that traits were inherited through proteins, but as Hershey and Chase showed, this is incorrect.
Alfred Hershey (shown above) and Martha Chase showed that traits are inherited through DNA through using markers and DNA and Proteins on bacteria, and seeing if the markers carried through to their offspring. The only marker that carried onto the bacteria's offspring was the marked DNA.
They convinced many scientists that DNA was the genetics material ground in gene
they dicovered DNA
Griffith, Avery, Hershey, and Chase
It is not Hershey and Chase !! It is Oswald Avery that conducted these experiments!
The assumption of inheritence material was first suggested by Griffith's experiments on diplococcus. Later on in 1944 three scientist; Avery, Macleod, and Mc. Carty repeated the Griffith's experiment and finally Harshey and Chase perform the experiment with bacteriophage and E.coli and prooved that DNA is a genetic material.
In their experiments, Hershey and Chase showed that when bacteriophages, which are composed of DNA and protein, infect bacteria, their DNA enters the host bacterial cell, but most of their protein does not. Although the results were not conclusive, and Hershey and Chase were cautious in their interpretation, previous, contemporaneous and subsequent discoveries all served to prove that DNA is the hereditary material.
According to my bio book, I think it's Alfred Hershey and Martha Chase, in the HERSHEY-CHASE experiment.
Griffith, Avery, Hershey, and Chase
Friedrich Miescher performed experiments in the lab at the University of Tubingen in 1868. He experimented with the chemical composition of leukocytes, and these experiments led to the discovery of DNA.
Griffith's Discovery of Transformation Avery's Experiments with nucleic acidsHershey-Chase Experiment
They showed that DNA contains genetic information.
They showed that DNA carries genetic information.
It is not Hershey and Chase !! It is Oswald Avery that conducted these experiments!
It is not Hershey and Chase !! It is Oswald Avery that conducted these experiments!
Bacteriophage
In 1928, Frederick Griffith was able to transform harmless bacteria into virulent pathogens with an extract that Oswald Avery proved, in 1944, to be DNA. In 1952, Martha Chase and Alfred Hershey used radioactively labeled virus DNA to infect bacteria, proving the same point.
In 1944, Oswald Avery, Colin MacLeod, and Maclyn McCarty published a paper demonstrating that DNA was the transforming factor.Their discovery was at first met with disbelief by some scientists, who thought that only proteins could have enough complexity to hold genetic information. Also, for a while some scientists thought bacteria might have a different genetic chemistry from other organisms.Avery
Hershey and Chase
DNA controls heredity, not proteins.