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For those who do not know, temazepam is an intermediate-acting 3-hydroxy benzodiazepine. It is generally prescribed for the short-term treatment of severe or debilitating sleeplessness in patients who have difficulty falling asleep or maintaining sleep. Overdosage of temazepam results in increasing CNS effects, including:

* Somnolence (difficulty staying awake) * Mental confusion * Respiratory depression * Hypotension * Impaired or absent reflexes * Impaired coordination * Impaired balance * Dizziness * Coma * Death

A 1993 British study found temazepam to have the highest number of deaths per million prescriptions among medications commonly prescribed in the 1980s (11.9, versus 5.9 for benzodiazepines overall, taken with or without alcohol). A 1995 Australian study of patients admitted to hospital after benzodiazepine overdose corroborated these results, and found temazepam overdose much more likely to lead to coma. Additionally, the combination of alcohol and temazepam makes death by alcohol poisoning more likely.

Overdose effects of temazepam are worsened in certain individuals with various preexisting diseases. Use of temazepam should be avoided, when possible, in individuals with the following conditions:

* Ataxia (lack of coordination of muscle movements) * Severe hypoventilation (slowed breathing) * Acute narrow-angle glaucoma (loss of vision) * Severe hepatic deficiencies (hepatitis and liver cirrhosis decrease elimination by a factor of 2) * Severe renal deficiencies (e.g. patients on dialysis) * Severe sleep apnea (closure of airway during sleep) * Severe depression, particularly when accompanied by suicidal tendencies * Acute intoxication with alcohol, narcotics, or other psychoactive substances * Myasthenia gravis (facial paralysis) * Hypersensitivity or allergy to any drug in the benzodiazepine class

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Q: What are symptoms of overdose of temazepan... Can this be fatal?
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