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DTC (DIAGNOSTIC TROUBLE CODE) P0306 IS CYLINDER #6 MISFIRE, MEANING THAT CYLINDER IS NOT RUNNING, EITHER IT BE BECAUSE OF AN IGNITION FAILURE OR FUEL (FAULTY INJECTOR) OR A VACCUM LEAK AT THAT CYLINDER

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Just adding to the answer :

On the Ford 6.8 liter gasoline V10 engine , the engine cylinder locations are numbered :

5 - 10

4 - 9

3 - 8

2 - 7

1 - 6

front of vehicle

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Q: What does Failure code PO306 on 1997 6.8 liter E350 Ford van mean?
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