What does the phrasethe best laid plans Of Mice and Men often go awry mean?

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It means that no matter how well laid out your plans are, there is always a chance that plan will not go the way you intended.
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Meaning of the title 'Of Mice and Men'?

There is a poem by Scottish Poet, Robert Burns, that goes "The best laid schemes of mice and men Gang aft a' gley (Often go wrong) and leave us nought but grief and pain f

What is the meaning of the phrase 'Of Mice and Men'?

Of course any phrase, saying or quote is context specific, thus for the sake or argument I will answer as treating the phrase context free (in terms of any authors who used it

What does the phrase 'the best laid plans Of Mice and Men often go awry' mean?

Meaning of ' the best-laid plans of mice and men often go awry '. Answer 1: The most carefully prepared plans may go wrong. Everybody makes plans