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What happens when heat-killed S-strain pneumococcus were injected into a mouse along with live R-strain pneumococcus?

Updated: 4/28/2022

Wiki User

∙ 15y ago

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A very important characteristic about bacteria actually created live S-strain to exist in the dead injected mouse. Bacteria is competent, in biological terms, meaning that cells can take up "naked" DNA from it's environment.

Knowing that fact, when the heat-killed S-strain pneumoccus mixed with the live R-strain, the R-strain took in the DNA, therefore inheriting the deadly coating of the S-strain. So the R became S, and killed the mouse.

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∙ 15y ago

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Q: What happens when heat-killed S-strain pneumococcus were injected into a mouse along with live R-strain pneumococcus?

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What did Avery's theory provide evidence for?

Ostwald T. Avery's experiment was an extension of the works of Griffith's. Griffith's experiment using virulent and avirulent Streptococcus pneumoniae (which had different colony characteristics) proved that it was possible for the heat killed virulent Streptococcus pneumoniae to pass on the genetic information for formation of smooth colonies to avirulent strains. Avery, Mc Leod and Mc Carty conclusively found out that the genetic material responsible for transfer of characteristics between the strains was DNA. This was achieved by incubating the cell lysate of virulent Streptococcus with proteases, RNAses and DNAses separately before mixing it with avirulent strains. It was found that only when the lysate was incubated with DNAses did the transfer of smooth colony formation characteristic from the virulent strain to the avirulent strain fail to occur.

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