Not being of the medical communmity, this first answer will be from the viewpoint of a layman, and will be best answered with a example. Imagine a wound which is beginning to skin over, but has not yet formed a hard scab. If one scrapes or removes that seal forming pre scab material, then that action is called exacerbation. In non medical use, the term exacerbation means to do something which irratates or makes a situation worse.
exacerbation; also called flare
That is the correct spelling of "exacerbation" (making a situation worse).
Acute in this context means short-term -- it hasn't been going on long. Exacerbation means signs and symptoms have gotten worse. "Acute exacerbation" of a disease means the disease has been there right along, but lately it's acting up. For example, in this season in our area (spring), I see many patients with acute exacerbation of allergies.
sudden & severe presentation of a pt with established PUD requiring hospital admission to manage may be defined as PUD exacerbation.
Synonyms for the noun exacerbation include worsening, aggravation, or heightening.When used to mean an emotional state, synonyms include irritation or annoyance.
Exacerbation
breakthrough pain
PNA=pneumonia
Exacerbation is the medical term meaning worsening.
making it worse by not taking the doctors advice or resting properly
An attack or exacerbation or flare
smoking, allergies, air particles, pollution