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It is a form of the actual drug of interest. The deuterate is different by + or - molecular weight (MW). In the case of GC/MS it has characteristics so similar to the drug of interest that it elutes (comes out) from the column as a peak with characteristic ions.
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Why internal standard you used in hplc method?
Internal standard can be used for calibration by plotting the ratio of the analyte signal to the internal standard signal as a function of the analyte concentration of the standards. This is done to correct for the loss of analyte during sample preparation or sample inlet.
What are the disadvantages of an internal standard in gas chromatography?
It has a poor efficiency for non-routine analysis. (you need to create an internal standard plot for each different ion you are measuring).
What is an unusual compound of water?
For example deuterated water (D2O), tritiated water (T2O) and HDO, HTO, DTO.
Deuterium is in one liter of heavy water?
The percentage of deuterated water (D2O and HDO) in normal water is approx. 0,015 %.
Why is it necessary to use an internal standard in the GLC assay?
Internal standard is primarily used to increase the accuracy and precision of analytical methods that have large inherent variability. The method is used in chromatography (GC, HPLC) where a compound similar to the analyte of interest is added to the sample and run. By having the analyte and the standard elute in the same run, the run to run variability is eliminated giving more precise results. Obviously one needs to calibrate the responses of the internal standard with that of the analyte. Incidental benefits are saving time and money by having less runs. Hope this is useful. Jay, Winnipeg, Canada
What is NaDCO3?
Deuterated sodium bicarbonate
Internal standard for melarsoprol?
yes
Why internal standard you used in hplc method?
Internal standard can be used for calibration by plotting the ratio of the analyte signal to the internal standard signal as a function of the analyte concentration of the standards. This is done to correct for the loss of analyte during sample preparation or sample inlet.
What is standard width of internal roads?
12 feet.
What are the disadvantages of an internal standard in gas chromatography?
It has a poor efficiency for non-routine analysis. (you need to create an internal standard plot for each different ion you are measuring).
Why is o-xylene used as an internal standard in this experiment?
Oxylene is used as an internal standard in experiments because it absorbs a wide area. It also absorbs other compounds easily.
What is an unusual compound of water?
For example deuterated water (D2O), tritiated water (T2O) and HDO, HTO, DTO.
What is the standard internal drive interface that you use today?
The most popular consumer internal drive interface is SATA.
Why internal standard use in GC?
We use internal standard for the identification of that compound which we want to know the concentration. No effect of the injection volume of sample. But Now a days Auto injector is coming very good quality, so we can control the injection volume of sample. So we do not need any internal standard. Nikhil
Why do law enforcement officials fail to recognize there no limit to the size of a deuterated lithium hybrid car battery bomb because plutonium-catalyzed therefore never reach critical mass?
They probably fail to recognize this because they are not terribly aware of what a deuterated lithium hybrid car battery bomb is or how it works.
Deuterium is in one liter of heavy water?
The percentage of deuterated water (D2O and HDO) in normal water is approx. 0,015 %.
What does symbolic data means-?
Symbolic data differ from standard data in that they contain internal variation.
