What is meant by frameshift mutation?

Answer 1

A frame shift mutation is one in which the "reading frame" for protein synthesis is altered.

Starting from the DNA, you have either the insertion or deletion of one or more base pairs (but not in a multiple of three). For example, onebase pairmay be inserted into the coding portion of a gene. This is transcribed into mRNA then taken to the ribosome to be "read" (translated) by the tRNA. However, tRNA has three bases on the end of it, which correspond to a specific amino acid. By adding one base into the sequence, you "shift" the reading frame by one base pair and completely change the entire remaining amino acid sequence.

Note that if you were to add or subtract three (or a multiple of three) base pairs, you would not shift the frame - you would add or subtract amino acids, but the remaining ones would be the same as the original sequence.

Answer 2

A frame shift mutation is one in which the "reading frame" for protein synthesis is altered.

Starting from the DNA, you have either the insertion or deletion of one or more base pairs (but not in a multiple of three). For example, onebase pairmay be inserted into the coding portion of a gene. This is transcribed into mRNA then taken to the ribosome to be "read" (translated) by the tRNA. However, tRNA has three bases on the end of it, which correspond to a specific amino acid. By adding one base into the sequence, you "shift" the reading frame by one base pair and completely change the entire remaining amino acid sequence.

Note that if you were to add or subtract three (or a multiple of three) base pairs, you would not shift the frame - you would add or subtract amino acids, but the remaining ones would be the same as the original sequence.

Answer 3

If a necleotude is added or deleted, the bases are still read in groups of three,but now those groupings are shifted for every codon that follows. Changes like those are known as frameshift mutations.

Answer 4

A frame shift mutation is one in which the "reading frame" for protein synthesis is altered.

Starting from the DNA, you have either the insertion or deletion of one or more base pairs (but not in a multiple of three). For example, onebase pairmay be inserted into the coding portion of a gene. This is transcribed into mRNA then taken to the ribosome to be "read" (translated) by the tRNA. However, tRNA has three bases on the end of it, which correspond to a specific amino acid. By adding one base into the sequence, you "shift" the reading frame by one base pair and completely change the entire remaining amino acid sequence.

Note that if you were to add or subtract three (or a multiple of three) base pairs, you would not shift the frame - you would add or subtract amino acids, but the remaining ones would be the same as the original sequence.

Answer 5

A frameshift mutation is a type of mutation involving the insertion or deletion of a nucleotide in which the number of deleted base pairs is not divisible by three.
"Divisible by three" is important because the cell reads a gene in groups of three bases. Each group of three bases corresponds to one of 20 different amino acids used to build a protein.
If a mutation disrupts this reading frame, then the entire DNA sequence following the mutation will be read incorrectly.
Here is an example of one sentence with words of only three letters:

The big red pig ate the red rag. Each word will make one amino acid and the words make a sentence that makes sense.

Mutations that replaces one base for another will result in this: The beg red peg ate the red rag. This mutation can be read OK.

But another type might make the sentence totally readable: The big res dpi gat eth ere dra g.

Answer 6

A frameshift mutation (or framing error) is a genetic mutation caused by an insertion or deletion of nucleotide(s) that's not evenly divisible by 3.