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The p53 is the tumor suppressor protein that regulates cell cycles and hence has a role in preventing cancer.
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What is the role of the transactiovation domain of p53?
p53 it ripari DNA demaged fragments.
What is the P53 gene function?
p53 is a gene that codes for a protein (p53) that is an important tumor suppressor. Although the number of pathways and roles of p53 continue to expand it is, perhaps, most well known for slowing cell proliferation or inducing apoptosis if DNA damage or uncontrolled growth is detected.
What type of gene is the p53 gene?
p53 (also known as protein 53 or tumor protein 53), is a tumor suppressor protein that in humans is encoded by the TP53gene. p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressorthat is involved in preventing cancer. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation.The name p53 is in reference to its apparent molecular mass: It runs as a 53-kilodalton (kDa) protein on SDS-PAGE. But, based on calculations from its amino acid residues, p53's mass is actually only 43.7 kDa. This difference is due to the high number of prolineresidues in the protein, which slows its migration on SDS-PAGE, thus making it appear heavier than it actually is. This effect is observed with p53 from a variety of species, including humans, rodents, frogs, and fish..
Can you explain the way an abnormal p53 causes normal cells to become cancer cells?
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What is P53 and what does it have to do with cancer?
The human gene known as p53 is a tumor suppressor gene and malfunctions of it have been implicated in many cancer types. Research is using it to study the biology of cancer, as well as to develop new drug targets to cure certain cancers.In 1993, p53 protein was named Molecule of the Year by Science magazine. It is a protein that is very important for the regulation of cell cycles in humans and other multi-cellular organisms. p53 is also known as TP53 and several other names including tumor protein (EC :2.7.1.37), the "guardian of the genome", and the "Guardian Angel Gene" (because it works to prevent mutation or damage to the genome).Most recent genetic research is also promising in the search for cancer causes and treatments. The research indicates there is a relationship between development of cancer and insufficiency of the p53 gene.More than 50% of the tumors in humans show a mutation of or deletion of this gene. It is believed that various things can cause the mutations or damage/deletion of p53, such as DNA damage from chemicals, UV ray damage, and there are some known viruses that can inhibit the function of p53, such as Simian Virus 40 (SV40) and Human Papillomavirus (HPV), an STD.These viruses and DNA damage can inactivate p53, rendering it ineffective for tumor suppression.See more in related questions and links.
What is the role of the transactiovation domain of p53?
p53 it ripari DNA demaged fragments.
What has the author Gerard P Zambetti written?
Gerard P. Zambetti has written: 'The p53 tumor suppressor pathway and cancer' -- subject(s): P53 antioncogene, P53 protein
What is the P53 gene function?
p53 is a gene that codes for a protein (p53) that is an important tumor suppressor. Although the number of pathways and roles of p53 continue to expand it is, perhaps, most well known for slowing cell proliferation or inducing apoptosis if DNA damage or uncontrolled growth is detected.
What cancers does the p53 cancer gene cause?
P53 it is an anzyme that monitorize the DNA and protect them from demagis.It is founded that its defective in 60% of cancer cells
A cell with a defective p53 gene is likely to?
A defective P53 gene is likely to cause poor regulation of cell cycles. P53 is a protein that suppresses tumor production and is implicated as a factor in cancer development. It prevents genome mutation and damage. 50% of human tumors have mutated or deleted P53 genes.
What is p53 called?
"The Guardian Angel Gene"
Who identified the p53 gene?
The p53 gene was identified in 1979 by Arnold Levine, David Lane, and William Old. It wasn't until 1989 that the gene was found to be a tumor suppressor.
What type of gene is the p53 gene?
p53 (also known as protein 53 or tumor protein 53), is a tumor suppressor protein that in humans is encoded by the TP53gene. p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressorthat is involved in preventing cancer. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation.The name p53 is in reference to its apparent molecular mass: It runs as a 53-kilodalton (kDa) protein on SDS-PAGE. But, based on calculations from its amino acid residues, p53's mass is actually only 43.7 kDa. This difference is due to the high number of prolineresidues in the protein, which slows its migration on SDS-PAGE, thus making it appear heavier than it actually is. This effect is observed with p53 from a variety of species, including humans, rodents, frogs, and fish..
What is the role of P53 in Cell Cycle Check Point?
The p53 Tumour suppressor gene is located on chromosome 17. As its name suggests, it has an anti-tumour activity. That involves the overseeing of the cell cycle. If either the cell or the DNA is impaired, p53 activates the production of specific chemicals (like p21 protein), which interferes with the cell cycle. Depending on the nature/extent of the damage, its either repaired, thus cell cycle is allowed to continue, or p53 initiate apoptosis (cell death). This mechanism would effectively stop the proliferation of infected (malignant) cells, however, p53 itself (or any of genes/chemicals p53 regulates) could be damaged/mutated. In the inherited condition, Li-Fraumeni syndrome, for example, only one functional copy of p53 gene is inherited (instead of two), which interferes with its normal function.
What role does p53 have in controlling cell division?
Cell division is regulated by the p53 gene and relates to cancer because Cancer is caused by uncontrolled cell divison
Why are loss-of-function mutations in p53 observed in more than half of all human cancers?
p53 normally functions as a tumor suppressor to stop the cell cycle after DNA damage occurs.
What would you expect cells to be like if they did not have properly functioning p53?
The absence of p53 could cause cells to copy damaged DNA, which could lead to mutations.
