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They are just different salts of the same drug: codeine. Different salts can exhibit different dissolution properties but in this case one company chose the sulphate the other chose the phosphate.

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9y ago
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9y ago

Basically yes.

Codeine base is not very water soluble, so it may be combined with a dilute strong acid, such as sulfuric acid. This make the codeine much more soluble, but it is no longer codeine base, but codeine sulfate.

If it was hydrochloric acid used instead, you would have codeine hydrochloride instead. Acetic acid would give you codeine acetate, etc......

Gram for gram, codeine sulfate has a little less codeine then the same mass of codeine base, because some of that mass is the sulfate group (and some water molecules).

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11y ago

One has phosphorus and oxygen, one doesn't.

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Q: What is the difference between penicillin and codeine sulphate?
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