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The most basic answer to this question is the combination of Serverity, Occurance and the ability to Detect a problem. Rating each of the three criteria (scale of 1-10) and the number that is generated from the combination will determine how an item is designated and controled, also whether corrective actions should be in place. However a high number (9 or 10) is only one catagory like Severity can automatically require a Critical Charicteristic rating.

Significant charicters can typically be controled using atribute data collected using a go-no go type check. Critical Charicteristics typically should have Variable data and be controled using SPC data collected and monitored for a level of predetermined CPK.

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Q: What is the difference between critical characteristics and significant characteristics?
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