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What is the difference between a tumor suppressor gene and an oncogene?
Wiki User
∙ 13y ago
Oncogenes regulate cell division, so if it is placed near an overly active gene, it may itself become overly active, thus causing cancer. Tumor suppressors suppress tumors and will only cause cancer if it stops its activity, contrary to oncogenes.
Wiki User
∙ 14y ago
Wiki User
∙ 13y agoTumor suppressor gene :- gene that protects a cell from one step on the path to cancer. It slows down cell division or cause cells to die at appropriate time.
Oncogenes: - an oncogene is a gene that, when mutated or expressed at high levels, helps turn a normal cell into a tumor cell.
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What effect does oncogenes have on cells?
Cells with an oncogene become over-stimulated to divide more often than normal. The chances of cancer developing are increased if a mutation to a tumor-suppressor gene also occurs. As an oncogene is a cancer-causing gene
What are tumor suppressor and oncogenes genes?
Tumor suppressor genes are normal genes that carry out several functions: * slow down cell division * repair mistakes made when DNA is being replicated * tell cells when to die (a process known as apoptosis or programmed cell death) A mutation in a tumor suppressor gene allows cells to grow out of control, which can lead to cancer ie the growth of a tumor. About 30 tumor suppressor genes have been identified, including p53, BRCA1, BRCA2, APC, and RB1. A good analogy for tumor suppressor genes is the brake pedal on a car - it normally keeps the cell from dividing too quickly just as a brake keeps a car from going too fast. If the brakes on a car fail, the car goes out of control; similarly, when something goes wrong with the gene, such as a mutation, cell division can get out of control. See: http://www.cancer.org/docroot/ETO/content/ETO_1_4x_oncogenes_and_tumor_suppressor_genes.asp http://envirocancer.cornell.edu/FactSheet/Genetics/fs6.TSgenes.cfm http://www.cancerquest.org/index.cfm?page=52
What are Stability Genes?
Stability genes are one of the three main genes, that when mutated are associated with cell progression towards tumorigenicity. It's normal function is to control the rate of mutation, but if mutated it off-balances, effecting oncogene and tumor suppressor function. In other words, accelerating the mutation process.
What is p53 marker?
The p53 is the tumor suppressor protein that regulates cell cycles and hence has a role in preventing cancer.
What are oncogenes and how do they affect the cell cycle?
The region of the viral genome (DNA in DNA tumor-viruses or RNA in RNA-tumor viruses) that can cause a tumor is called an oncogene. This foreign gene can be carried into a cell by the virus and cause the host cell to take on new properties such as immortalization and anchorage-independent growth.
What are two types of genes that when disrupted can cause cancer?
The two genes considered responsible for the cause of cancer are the oncogene and the tumor suppressor gene.
What effect does oncogenes have on cells?
Cells with an oncogene become over-stimulated to divide more often than normal. The chances of cancer developing are increased if a mutation to a tumor-suppressor gene also occurs. As an oncogene is a cancer-causing gene
What are tumor suppressor and oncogenes genes?
Tumor suppressor genes are normal genes that carry out several functions: * slow down cell division * repair mistakes made when DNA is being replicated * tell cells when to die (a process known as apoptosis or programmed cell death) A mutation in a tumor suppressor gene allows cells to grow out of control, which can lead to cancer ie the growth of a tumor. About 30 tumor suppressor genes have been identified, including p53, BRCA1, BRCA2, APC, and RB1. A good analogy for tumor suppressor genes is the brake pedal on a car - it normally keeps the cell from dividing too quickly just as a brake keeps a car from going too fast. If the brakes on a car fail, the car goes out of control; similarly, when something goes wrong with the gene, such as a mutation, cell division can get out of control. See: http://www.cancer.org/docroot/ETO/content/ETO_1_4x_oncogenes_and_tumor_suppressor_genes.asp http://envirocancer.cornell.edu/FactSheet/Genetics/fs6.TSgenes.cfm http://www.cancerquest.org/index.cfm?page=52
What is pro- oncogene?
An oncogene is a gene, when mutated or expressed at high levels it helps turn a normal cell into a tumor cell.
What is the p35 cancer gene?
tumor suppresser gene that could turn into an oncogene
What are Stability Genes?
Stability genes are one of the three main genes, that when mutated are associated with cell progression towards tumorigenicity. It's normal function is to control the rate of mutation, but if mutated it off-balances, effecting oncogene and tumor suppressor function. In other words, accelerating the mutation process.
Where can one find information about Tumor Suppressor Genese?
You can find information about Tumor Suppressor Genes in Bio Portfolio, Chips Books, Cancer Res, Academic Research Microsoft, Nature,Freezing Blue, Cancer 2000.
Explain how mutations in tumor suppressor genes can contribute to cancer?
Well, tumor suppressor genes are basically proteins that regulate the eradication of cells that develop mutations in the G1 or G2 phase of the cell cycle. For example, lets say a 54 year old patient has the Trp53 tumor suppressor protein mutation. What this means is that this patient has less of an ability to sense cells with mutations in the pancreas because they are deficient or void of the tumor suppressor protein, Trp53. Thus, this patient has an increased risk of pancreatic Adenocarcinoma, the most common form of pancreatic cancer.
What is apc?
APC is classified as a tumor suppressor gene. Tumor suppressor genes prevent the uncontrolled growth of cells that may result in cancerous tumors. The protein made by the APC gene plays a critical role in several cellular processes that determine whether a cell may develop into a tumor.
What is the difference between the scirrhous cancer and the encephaloid cancer?
The encephaloid tumor is hard and the scirrhous tumor is hot
Difference between proto-oncogenes and tumor suppressor genes?
During the division of the cell membrane (CYTOKINESIS), animal cells divide the cytoplasm by constricting the cell membrane in the middle to form a CLEAVAGE FURROW while plant cells form a CELL PLATE.
The two types of cell cycle genes if mutated cause cancer cells to divide uncontrollably are called tumor suppressor genes and?
The two types of cell cycle genes that cause cancer cells to divide uncontrollably if mutated are called tumor suppressor genes and antioncogene
