Down syndrome is an abnormality of the chromosomes and not genic in origin .This occurs in one of every two thousand newborns. People do not "carry" this and the child is born with three rather than two chromosomes numbered 21. The mother and father of the child are normal except in the rare case of a woman with Down syndrome who gives birth to a child; the copying or replication error occurs either in the germ cell or in the initial cell division of the embryo.
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In the US, there are currently almost 500,000 people with Down Syndrome.
http://www.ds-health.com/risk.htm
That is hard to say because the frequency of Down syndrome if a function of maternal age so it is not fixed. A mom between 20 and 24 years old has a 1/ 1400 risk of having a child with Down syndrome. A mom who is 45 or older has a 1/25 risk. Overall, it is fair to say Down syndrome is one of the most common and best known genetic disease. Other genetic disease such as Cystic Fibrosis, hemochromatosis are also common. The frequency of all these things varies in different populations as well as age. So the question is quite hard to answer without isolating a specific population.
1 out of every 691 live births
0-9 purcent
For the United States, estimated as the fraction of people in the population with the syndrome, ~1/5500.
There are approximately7,222,222 people with down syndrome in the world ( if you compare the stat 1 in every 800-1000 births to the world's population of 6.5 billion).
down syndrome
Disorders, such as Down's Syndrome, are caused by nondisjunction.
Down syndrome
Down syndrome is generally the preferred spelling, although Down's syndrome is sometimes used in American sources.