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I can not provide an estimate.

In calculation of flow out of a pipe, more information would be needed. Since you have asked this under the category of the oil spill, I assume you are asking what is the flow of oil out a vertical pipe, if the pressure at the bottom is 40,000 psi, and the diameter is 21". You need to specify the length of the pipe and all properties of the fluid. Since you are asking this in relation to the BP oil spill, gas will come out of solution as the oil is coming to the surface (or sea floor) making the calculations far from simple. There are a number of commercial pipe flow simulators.

Again, for the BP spill, a team of scientists and engineers are using pipe flow simulation , if possible, and other methods to estimate the flow.

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Q: What is the liquid flow rate of a 21 diameter pipe at 40000 psi?
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