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What is the most widely used and abused depressant in the united states?

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alcohol
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What is the most abused nervous system depressant?

Alcohol. It is a CNS (central nervous system) depressant. this is a guess on what is the most used - but it seems like a logical one. THC (marijuana) is not technically a CNS

The most commonly abused drug in the United States is?

Probably alcohol. Alcohol is the most widely-used drug everywhere in the world, so, I would assume it is also the most widely-abused drug. Since it is legal, it is the easie