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What is wrong with a one year old milk snake that has been less active and isn't eating his thawed frozen mice?

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Maybe the size of mouse you are giving him is too big.

Make sure the mouse is hot enough. Put the mouse in your snake's cage then cover it with a sheet and turn out the lights. Snakes see in heat so they can sense heat better in the dark. Don't move onto live mice yet. The live mouse could bite the snake in self defense and result in injury. Try a smaller size mouse first.
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