What subway do you take from Penn Station to 435 Hudson Street?

Answer 1

You can take the Downtown 1 or 2 (of the 1-2-3, the red line) from 34th Street-Penn Station to Canal Street (at Varick Street).

You can also take the Downtown A-C-E (the blue line) from 34th Street-Penn Station to Canal Street (at 6th Avenue, only one block east of the Canal Street Station on the 1 and 2trains).

Or, you can take the Uptown 1-2-3 one stop, from 34th Street-Penn Station to 42nd Street-Times Square, and then transfer at Times Square to the Downtown N, R or Qtrains (of the N-R-Q-W, the yellow line) to Canal Street (at Broadway, a few blocks east of the Canal Street Station on the A-C-E).

The 6 train (of the 4-5-6, the dark green line) also stops at Canal Street, but you'd have to make two transfers to get to it from Penn Station, and the Canal Street Station on the 6 train is actually connected to the Canal Street Station on the N, R and Q trains. So you might as well just take the N, R or Q.

Answer 2

Take the Uptown 1-2-3 (the red line), one stop, from 34th Street-Penn Station to 42nd Street-Times Square.

Transfer at the Times Square Station to the Downtown N-R-Q (the yellow line) to 14th Street-Union Square.

Answer 3

Take the Downtown 1 local train (of the 1-2-3, the red line) from 34th Street-Penn Station to Houston Street (at Varick Street).

Depending on which exit you use, you might exit the subway on Varick Street between Houston Street and King Street (the next street down). Walk down to King Street, turn right, and walk 1 block east on King Street to Hudson Street. Turn left, and walk roughly 1/2 a block down to 350 Hudson Street, between King and Charlton Streets.