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Yes, patients with chronic kidney disease can be anemic. It is thought that decreased levels of erythropoietin from the diseased kidney result in lower hemoglobin and hematocrit. Specifically, from NHANES: the prevalence of anemia was 1% in patients with eGFR of 60 mL/min (higher is better for estimation of kidney function), patients with eGFR of 30 mL/min had a prevalence of 9%, and eGFR of 15 mL/min had up to 67%. Other causes of anemia should be worked ruled out before you and your primary care physician pursue increasing or supplementing erythropoietin.

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14y ago
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9y ago

Erythropoietin is the hormone released by the kidneys to stimulate the bone marrow to produce more RBCs
The kidney controls red blood cell levels by secreting the hormone erythropoietin. Patients with failing kidneys often are deficient in this hormone.

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15y ago

There are actually a couple reasons for this - I'll try to explain as best I can in plain language (sometimes hard to do).

Chronic kidney disease frequently causes a chronic inflammatory state (especially if caused by Diabetes, Arthritis, lupus, etc) and causes the body to have difficulty utilizing iron stores in the body. This is not only caused by kidney disease - many chronic conditions, including lupus, rheumatoid arthritis, etc, can cause this. It is called anemia of chronic disease.

Yet another reason people with renal failure become anemic is because the kidneys produce the hormone that stimulates the bone marrow to produce red blood cells - erythropoietin. When the kidneys shut down, they no longer make enough of this hormone, and so the body does not make enough red blood cells - hence anemia.

Another reason is because many people are on dialysis with chronic renal failure, which causes red blood cells to be more likely to break down. Dialysis also causes an inflammatory state in the body (due to interaction of blood with the dialysis machine) and so this increases the anemia of chronic disease and inability to utilize iron stores.

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14y ago

Enzyme produced by kidney to compensate for low hemoglobin level in blood which is required for oxygen distribution

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11y ago

People with kidney disease are prone for anemia as the kidney is a site for production of the hormone Erythropoietin which is a primary regulator of RBC production.

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12y ago

as the overal function of the kidneys declines they produce less of erythropoetin which normally stimulates the bone marrow to produce red blood cells. As this declines anemia worsens.

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12y ago

because anemia is when there is not enough iron in the blood. my mum had it once

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12y ago

because the blood is not going the kidneys to flyush them out.

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13y ago

i want answer

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Q: Why do people with advanced kidney disease commonly become anemic?
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Why do people with advanced kidney disease commonly become anemic or have reduced RBCs count or levels of hemoglobin?

Part of it is that kidneys produce erythropoetin, which is a hormone that stimulates red blood cell production in normal people. In kidney disease, this process is diminished. Also, it is thought that people with some chronic diseases develop what is called "anemia of chronic disease" and it's not clear how this is played out, but it leads to chronic anemia . Also, people with kidney disease are often fluid over-loaded, and may have a dilutional effect, where the hematocrit and hemoglobin concentration seems lower than it actually is due to so much fluid in the system. So it's likely due to a combination of the above reasons.


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