methotrexate: Definition from Answers.com
... goal of the low dose methotrexate regimen is to inhibit AICAR transformylase
, which leads to increased AICA ribose (AICAR transformylase's substrate). ...
www.answers.com/topic/methotrexate

Transformylase - Health Encyclopedia
May 26, 2006 ... These and other data obtained with pteroylglutamic analogues show that, in
contrast to the bacterial enzyme, Euglena transformylase is also ...
www.steadyhealth.com/encyclopedia/Transformylase

Transformylase - WrongDiagnosis.com
Transformylase information including symptoms, causes, diseases, symptoms,
treatments, and other medical and health issues.
www.wrongdiagnosis.com/medical/transformylase.htm

Localization of GAR transformylase in Escherichia coli and ...
The third step is catalyzed by the enzyme glycinamide ribonucleotide
transformylase (GAR Tfase). This enzyme is monofunctional in E. coli, but exists
as ...
www.pnas.org/content/98/12/6565.full

Crystal structure of a bifunctional transformylase and ...
One of the activities of ATIC is AICAR transformylase (AICAR Tfase), which
catalyzes the formylation of 5-aminoimidazole-4-carboxamide-ribonucleotide ...
www.nature.com/nsmb/journal/v8/n5/full/nsb0501_402.html

Characterization of Molecularly Cloned Human 5-Aminoimidazole-4 ...
Northern-blot analysis of human AICAR transformylase mRNA showed the expression
... GST-AICAR transformylase can be purified to homogeneity by a single-step ...
jb.oxfordjournals.org/cgi/content/abstract/122/2/309

Effect of cobalamin inactivation on folate-dependent ...
The fall in glycinamide ribotide transformylase activity was prevented by ...
Activity of glycinamide ribotide transformylase recovers after 7 days despite
...
www.pubmedcentral.nih.gov/ articlerender.fcgi?artid=1144809

Localization of GAR transformylase in Escherichia coli and ...
transformylase (GAR Tfase) was monitored in live Escherichia coli and mammalian
cells. ... Tfase) and aminoimidazole ribonucleotide transformylase ...
www.pnas.org/cgi/reprint/121182998v1.pdf

Detection of inhibition of 5-aminoimidazole-4-carboxamide ribotide ...
The modified assay was used to detect the transformylase activity in crude
extracts of peripheral-blood mononuclear cells (PBMCs). ...
www.pubmedcentral.nih.gov/ articlerender.fcgi?artid=1149705

Crystal Structures of Human Bifunctional Enzyme Aminoimidazole- 4 ...
4-carboxamide Ribonucleotide Transformylase/IMP Cyclohydrolase ... inhibition of
the AICAR transformylase active site, com- ...
www.jbc.org/cgi/reprint/279/17/18034.pdf