Vázquez (or Vásquez, Vásques) is a Galician-Spanish surname.
- Andres Vasquez, a Peruvian-born Swedish football midfielder.
- Andrew Vasquez, Native American flute player
- Catalina Vasquez Villalpando, treasurer of the United States
- Christian Vásquez, Filipino model and actor
- Domingo Vásquez, president of Honduras 1893-08-07 - 1894-02-22
- Eric Vasquez, an American soccer player
- Fabio Vásquez Castaño, a Colombian rebel and revolutionary
- Felix Vasquez, Bronx hero
- Fernando Vázquez, Spanish football manager
- Fran Vázquez, Spanish basketball player
- Francisco Vásquez de Coronado, a Spanish conquistador
- Gabriel Vásquez, a Spanish Jesuit theologian
- Gaddi Vasquez, the 8th United States Representative to the United Nations Food and Agriculture Organization
- Horacio Vásquez, a Dominican general and political figure
- Ian Vásquez, director of the Cato Institute's Center for Global Liberty and Prosperity
- Israel Vázquez, Mexican boxer
- Javier Vázquez, Puerto Rican-American baseball pitcher
- Jennifer Vasquez, contestant in Big Brother 6
- Jhonen Vasquez, cartoonist
- Jorge Vásquez, a major league baseball pitcher
- Joseph Vásquez, an American independent filmmaker
- Juan Vásquez (composer), a Spanish priest and composer of the renaissance
- Julio César Vásquez, a professional boxer in the super middleweight (168lb) division
- Junior Vasquez, a New York City club DJ and remixer/producer
- La La Vasquez, Puerto Rican MTV VJ
- Louis Vásquez, a mountain man and trader from Missouri
- Lucas Vásquez de Ayllón, Spanish explorer
- Mario Vazquez, Arista Records' R&B artist of American Idol fame
- Martin Vasquez, Mexican soccer player
- Mona Vasquez, a critic of Scientology
Orlando Vásquez , a Nicaraguan weightlifter- Ramón Vázquez, an American baseball player
- Randy Vasquez, an American actor
- Rafael Vásquez, a Peruvian politician and a Congressman
- Rafael Martín Vázquez, a Spanish footballer
- Roberta Vasquez, a Cuban-American model, actress and Playboy playmate
- Roberto Vásquez, a southpaw boxer in the flyweight division
- Salvador Vasquez, a Peruvian-born Swedish football midfielder
- Sammy Vasquez, a martial artist
- Tabaré Vázquez, current President of Uruguay
- Tiburcio Vásquez, a Mexican bandit
- Walter Vásquez Vejarano, a Peruvian lawyer, politician and President of the Supreme Court
- Vásquez, a rock band featuring Ricky "the Atomic Elf" Bacchus
Fictional People
- Lt. Vasquez, platoon leader in the USMC 1st Force Recon in the 2007 video game Call of Duty 4: Modern Warfare
- Pvt. J. Vasquez, one of the fictional United States Colonial Marines in the 1986 film Aliens
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