
n.
A naturally occurring ester of three fatty acids and glycerol that is the chief constituent of fats and oils.
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American Heritage Dictionary:
tri·glyc·er·ide |

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Britannica Concise Encyclopedia:
triglyceride |
For more information on triglyceride, visit Britannica.com.
McGraw-Hill Science & Technology Encyclopedia:
Triglyceride |
A simple lipid. Triglycerides are fatty acid triesters of the trihydroxy alcohol glycerol which are present in plant and animal tissues, particularly in the food storage depots, either as simple esters in which all the fatty acids are the same or as mixed esters in which the fatty acids are different. The triglycerides constitute the main component of natural fats and oils.
The generic formula of a triglyceride is shown

The physical and chemical properties of fats and oils depend on the nature of the fatty acids present. Saturated fatty acids give higher-melting fats and represent the main constituents of solid fats, for example, lard and butter. Unsaturation lowers the melting point of fatty acids and fats. Thus, in the oil of plants, unsaturated fatty acids are present in large amounts, for example, oleic acid in olive oil and linoleic and linolenic acids in linseed soil. See also Fat and oil (food); Lipid.
Oxford Food & Nutrition Dictionary:
triglycerides |
Esters of fatty acids with glycerol, more correctly called triacylglycerols.
Oxford A-Z of Medicinal Drugs:
triglycerides |
| trifluoperazine, trientine dihydrochloride, tricyclic antidepressants | |
| trihexyphenidyl hydrochloride, trilostane, trimethoprim |
Gale Encyclopedia of Public Health:
Triglycerides |
"Triglycerides" is the chemical name for fat. Chemically, triglycerides have a three-carbon backbone (glycerol) to which are attached fatty acids, which are strings of carbon and hydrogen atoms, most of which will eventually be oxidized to carbon dioxide and water, producing energy in the process. When not being actively oxidized or metabolized, triglycerides are stored in adipose, or fatty tissue, for oxidation at a later time. High levels of triglycerides in the blood have been associated with increased risk for heart attacks and strokes. Triglycerides may be increased by heredity, abdominal obesity, resistance to insulin, diabetes, and certain medications. They may be decreased by weight loss, control of glucose in diabetes, decreased simple sugar intake in the diet, and increased activity.
(SEE ALSO: Atherosclerosis; Blood Lipids; Cholesterol Test; Genetics and Health; HDL Cholesterol; Hyperlipidemia; LDL Cholesterol; Nutrition; VLDL Cholesterol)
— DONALD A. SMITH
Gale Encyclopedia of Diets:
Triglycerides |
| KEY TERMS Adipose tissue — A type of connective tissue that contains stored cellular fat. Malnutrition —Poor nutrition because of an insufficient or poorly balanced diet or faulty digestion or utilization of foods Malabsorption —Poor absorption of nutrients by the intestinal tract Pancreas—A long, irregularly-shaped gland near the stomach that secretes a digestive fluid into the intestine through one or more ducts and that secretes the insulin, glucagen, and somatostatin into the bloodstream. Polycystic ovary syndrome —A condition in which cysts in the ovary interfere with normal ovulation and menstruation |
| Normal | Less than 150 mg/dL |
| Borderline-high | 150-199 mg/dL |
| High | 200-499 mg/dL |
| Very high | 500 mg/dL or above |
| SOURCE: National Heart, Lung and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services |
Columbia Encyclopedia:
triglyceride |
Wiley Dictionary of Flavors:
Triglyceride |
Oxford Dictionary of Biochemistry:
triglyceride |
| trigger factor, trigger, trifunctional protein | |
| trigonelline, trihydric, triiodothyronine |
Saunders Veterinary Dictionary:
triglyceride |
A compound consisting of three molecules of fatty acids bound with one molecule of glycerol; a neutral fat that is the usual storage form of lipids in animals.
Random House Word Menu:
categories related to 'triglyceride' |
Wikipedia on Answers.com:
Triglyceride |
A triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids.[1] There are many triglycerides, depending on the oil source, some are highly unsaturated, some less so.
Saturated compounds are "saturated" with hydrogen. Unsaturated compounds have double bonds (C=C) between carbon atoms. Saturated compounds have single bonds (C-C) between the carbon atoms, and the other bond is bound to hydrogen atoms (for example =CH-CH=, -CH2-CH2-, etc.).
Unsaturated fats have a lower melting point and are more likely to be liquid. Saturated fats have a higher melting point and are more likely to be solid.
Triglycerides are the main constituents of vegetable oil (typically more unsaturated) and animal fats (typically more saturated).[2] In humans, triglycerides are a mechanism for storing unused calories, and their high concentrations in blood correlates with the consumption of starchy and fatty foods.
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Contents
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Triglycerides are formed by combining glycerol with three molecules of fatty acid. Alcohols have a hydroxyl (HO-) group. Organic acids have a carboxyl (-COOH) group. Alcohols and organic acids join to form esters. The glycerol molecule has three hydroxyl (HO-) groups. Each fatty acid has a carboxyl group (-COOH). In triglycerides, the hydroxyl groups of the glycerol join the carboxyl groups of the fatty acid to form ester bonds:
The three fatty acids (RCO2H, R'CO2H, R''CO2H in the above equation) are usually different, but many kinds of triglycerides are known. The chain lengths of the fatty acids in naturally occurring triglycerides vary, but most contain 16, 18, or 20 carbon atoms. Natural fatty acids found in plants and animals are typically composed of only even numbers of carbon atoms, reflecting the pathway for their biosynthesis from the two-carbon building-block acetyl CoA. Bacteria, however, possess the ability to synthesise odd- and branched-chain fatty acids. As a result, ruminant animal fat contains odd-numbered fatty acids, such as 15, due to the action of bacteria in the rumen. Many fatty acids are unsaturated, some are polyunsaturated, e.g., those derived from linoleic acid.[citation needed]
Most natural fats contain a complex mixture of individual triglycerides. Because of this, they melt over a broad range of temperatures. Cocoa butter is unusual in that it is composed of only a few triglycerides, derived from palmitic, oleic, and stearic acids.[citation needed]
The enzyme pancreatic lipase acts at the ester bond, hydrolysing the bond and "releasing" the fatty acid. In triglyceride form, lipids cannot be absorbed by the duodenum. Fatty acids, monoglycerides (one glycerol, one fatty acid), and some diglycerides are absorbed by the duodenum, once the triglycerides have been broken down.
Triglycerides, as major components of very-low-density lipoprotein (VLDL) and chylomicrons, play an important role in metabolism as energy sources and transporters of dietary fat. They contain more than twice as much energy (9 kcal/g or 38 kJ/g ) as carbohydrates and proteins. In the intestine, triglycerides are split into monoacylglycerol and free fatty acids in a process called lipolysis, with the secretion of lipases and bile, which are subsequently moved to absorptive enterocytes, cells lining the intestines. The triglycerides are rebuilt in the enterocytes from their fragments and packaged together with cholesterol and proteins to form chylomicrons. These are excreted from the cells and collected by the lymph system and transported to the large vessels near the heart before being mixed into the blood. Various tissues can capture the chylomicrons, releasing the triglycerides to be used as a source of energy. Fat and liver cells can synthesize and store triglycerides. When the body requires fatty acids as an energy source, the hormone glucagon signals the breakdown of the triglycerides by hormone-sensitive lipase to release free fatty acids. As the brain cannot utilize fatty acids as an energy source (unless converted to a ketone), the glycerol component of triglycerides can be converted into glucose, via glycolysis by conversion into Dihydroxyacetone phosphate and then into Glyceraldehyde 3-phosphate, for brain fuel when it is broken down. Fat cells may also be broken down for that reason, if the brain's needs ever outweigh the body's.
Triglycerides cannot pass through cell membranes freely. Special enzymes on the walls of blood vessels called lipoprotein lipases must break down triglycerides into free fatty acids and glycerol. Fatty acids can then be taken up by cells via the fatty acid transporter (FAT).
In the human body, high levels of triglycerides in the bloodstream have been linked to atherosclerosis and, by extension, the risk of heart disease and stroke. However, the relative negative impact of raised levels of triglycerides compared to that of LDL:HDL ratios is as yet unknown. The risk can be partly accounted for by a strong inverse relationship between triglyceride level and HDL-cholesterol level.
The American Heart Association has set guidelines for triglyceride levels:[3][dead link]
| Level mg/dL | Level mmol/L | Interpretation |
| <150 | <1.70 | Normal range, low risk |
| 175-199 | 1.70-2.25 | Slightly above normal |
| 200-499 | 2.26-5.65 | |
| >500 | >5.65 | Very high: high risk |
These levels are tested after fasting 8 to 12 hours. Triglyceride levels remain temporarily higher for a period of time after eating.
Diets high in carbohydrates, with carbohydrates accounting for more than 60% of the total energy intake, can increase triglyceride levels.[3] Of note is how the correlation is stronger for those with higher BMI (28+) and insulin resistance (more common among overweight and obese) is a primary suspect cause of this phenomenon of carbohydrate-induced hypertriglyceridemia.[4]
There is evidence that carbohydrate consumption causing a high glycemic index can cause insulin overproduction and increase triglyceride levels in women.[5]
Adverse changes associated with carbohydrate intake, including triglyceride levels, are stronger risk factors for heart disease in women than in men.[6]
Triglyceride levels are also reduced by exercise and by consuming omega-3 fatty acids from fish, flax seed oil, and other sources. See potential health benefits of Omega-3.
Carnitine has the ability to lower blood triglyceride levels.[7] In some cases, fibrates have been used to bring down triglycerides substantially.[8]
Heavy use of alcohol can elevate triglycerides levels.[9]
Linseed oil and related oils are important components of useful products used in oil paints and related coatings. Linseed oil is rich in di- and triunsaturated fatty acid components, which tend to harden in the presence of oxygen. The hardening process is peculiar to these so-called "drying oils". It is caused by a polymerization process that begins with oxygen's attacking the carbon backbone.
Triglycerides are also split into their components via transesterification during the manufacture of biodiesel. The resulting fatty acid esters can be used as fuel in diesel engines. The glycerin has many uses, such as in the manufacture of food and in the production of pharmaceuticals.
Staining for fatty acids, triglycerides, lipoproteins, and other lipids is done through the use of lysochromes (fat-soluble dyes). These dyes can allow the qualification of a certain fat of interest by staining the material a specific color. Some examples: Sudan IV, Oil Red O, and Sudan Black B.
Click on genes, proteins and metabolites below to link to respective articles. [10]
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| MCT | |
| glyceride | |
| triacylglycerol |
| How is a triglyceride formed? Read answer... | |
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| Are triglycerides is carbohydrates? Read answer... |
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