80 miles taking this route: .
Follow U.S. 378 EAST (Garner's Ferry Road in Columbia), towards SUMTER, from Columbia, to U.S. 52, at Lake City (beyond JCT I-95). EXIT off of… U.S. 378 onto U.S. 52, and turn left off the exit ramp onto U.S. 52 NORTH to FLORENCE. .
Take U.S. 52 NORTH (2 miles) to Scranton, SC. ( Full Answer )