1-Aminocyclopropane-1-carboxylic acid
Oxford Dictionary of Biochemistry:
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1-aminocyclopropane-1-carboxylic acid
abbr.: ACC; a cyclic α-amino acid that is the immediate precursor of the plant hormone ethylene. ACC is produced by ACC synthase in the reaction:
S-adenosylmethionine = ACC + 5′-methylthioadenosine.
ACC produces ethylene in the reaction catalysed by ACC oxidase:
ACC + 1/2O2 = ethylene + CO2 + HCN + H2O.
ACC is also a potent and selective ligand for the glycine modulatory site of the NMDA receptor (see glutamate receptor).
Wikipedia on Answers.com:
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1-Aminocyclopropane-1-carboxylic acid
| 1-aminocyclopropane-1-carboxylic acid | |
|---|---|
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| Identifiers | |
| Abbreviations | ACC |
| CAS number | 22059-21-8 |
| PubChem | 535 |
| ChemSpider | 520  |
| DrugBank | DB02085 |
| KEGG | C01234 |
| ChEBI | CHEBI:58360 |
| ChEMBL | CHEMBL265325 |
| Jmol-3D images | [1] Image 1 Image 2 |
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| Properties | |
| Molecular formula | C4H7NO2 |
| Molar mass | 101.1 g mol−1 |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
1-Aminocyclopropane-1-carboxylic acid (ACC) is a disubstituted cyclic alpha-amino acid in which a three-membered cyclopropane ring is fuzed to the C(alpha)-atom of the amino acid.
ACC plays an important role in the biosynthesis of the plant hormone ethylene.[2][3] It is synthesized by the enzyme ACC synthase ( EC 4.4.1.14) from methionine and converted to ethylene by ACC oxidase (EC 1.14.17.4).[4]
ACC is also a non-physiological partial agonist of the mammalian NMDA receptor.[5]
References
- ^ Caspi R, Foerster H, Fulcher CA, Hopkinson R, Ingraham J, Kaipa P, Krummenacker M, Paley S, Pick J, Rhee SY, Tissier C, Zhang P, Karp PD (2006). "MetaCyc: a multiorganism database of metabolic pathways and enzymes". Nucleic Acids Res. 34 (Database issue): D511–6. doi:10.1093/nar/gkj128. PMC 1347490. PMID 16381923. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1347490.
- ^ Yang S, Hoffman N (1984). "Ethylene biosynthesis and its regulation in higher plants". Annu. Rev. Plant Physiol. 35: 155–189. doi:10.1146/annurev.pp.35.060184.001103.
- ^ Kende H (1993). "Ethylene biosynthesis". Annu. Rev. Plant Physiol. 44: 283–307. doi:10.1146/annurev.pp.44.060193.001435.
- ^ Kende H (1989). "Enzymes of Ethylene Biosynthesis". Plant Physiol. 91 (1): 1–4. doi:10.1104/pp.91.1.1. PMC 1061940. PMID 16666977. http://www.plantphysiol.org/cgi/content/abstract/91/1/1.
- ^ Inanobe A, Furukawa H, Gouaux E (2005). "Mechanism of partial agonist action at the NR1 subunit of NMDA receptors". Neuron 47 (1): 71–84. doi:10.1016/j.neuron.2005.05.022. PMID 15996549.
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