1-Octacosanol
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1-Octacosanol
| 1-Octacosanol | |
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Octacosan-1-ol |
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Other names
n-Octacosanol; Octacosyl alcohol; Octanosol; Montanyl alcohol; Cluytyl alcohol |
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| Identifiers | |
| CAS number | 557-61-9  |
| PubChem | 68406 |
| ChemSpider | 61689  |
| UNII | 81I2215OVK |
| KEGG | C08387 |
| MeSH | 1-octacosanol |
| ChEBI | CHEBI:28243 |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C28H58O |
| Molar mass | 410.76 g mol−1 |
| Melting point |
83 °C, 356 K, 181 °F |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
1-Octacosanol (also known as n-octacosanol, octacosyl alcohol, cluytyl alcohol, montanyl alcohol) is a straight-chain aliphatic 28-carbon primary fatty alcohol that is common in the epicuticular waxes of plants, including the leaves of many species of Eucalyptus, of most forage and cereal grasses, of Acacia, Trifolium, Pisum and many other legume genera among many others, sometimes as the major wax constituent.[1] Octacosanol also occurs in wheat germ.[2]
Chemistry
Octacosanol is insoluble in water but freely soluble in low molecular-weight alkanes and in chloroform.
Biological effects
Octacosanol is the main ingredient of policosanol and it has a variety of pharmacological effects,[3] and may help patients with Parkinson's disease.[4][5]
References
- ^ EA Baker (1982) Chemistry and morphology of plant epicuticular waxes. pp139-165. In "The Plant Cuticle". edited by DF Cutler, KL Alvin and CE Price. Academic Press, London. ISBN 0-12-199920-3
- ^ "Octacosanol". Natural Products (Professional). drugs.com. Archived from the original on 03 June 2009. http://web.archive.org/web/20090603230755/http://www.drugs.com/npp/octacosanol.html. Retrieved 09-July-2009. "isolated from wheat germ oil or other plants"
- ^ Taylor, Johanna C; Rapport, Lisa; Lockwood, G.Brian (2003). "Octacosanol in human health". Nutrition 19 (2): 192–5. doi:10.1016/S0899-9007(02)00869-9. PMID 12591561.
- ^ Snider, SR (1984). "Octacosanol in parkinsonism". Annals of neurology 16 (6): 723. doi:10.1002/ana.410160615. PMID 6395790.
- ^ Wang, T; Liu, YY; Wang, X; Yang, N; Zhu, HB; Zuo, PP (2010). "Protective effects of octacosanol on 6-hydroxydopamine-induced Parkinsonism in rats via regulation of ProNGF and NGF signaling". Acta pharmacologica Sinica 31 (7): 765–74. doi:10.1038/aps.2010.69. PMID 20581854.
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