17Beta Hydroxysteroid dehydrogenase: Information from Answers.com

17Beta Hydroxysteroid dehydrogenase

Identifiers

AmiGO / EGO

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Steroidogenesis. 17Beta HSD visible at left.

The 17β-hydroxysteroid dehydrogenases (17β-HSD enzymes) are a group of alcohol oxidoreductases which catalyse the dehydrogenation of 17-hydroxysteroids in steroidogenesis.

Genes

Genes coding for 17β-HSD include:

Clinical significance

Isozyme 3 is responsible for 17-beta-hydroxysteroid dehydrogenase deficiency.

References

MeSH 17+beta-Hydroxysteroid+Dehydrogenases

This oxidoreductase article is a stub. You can help Wikipedia by expanding it.

v • d • e Oxidoreductases: alcohol oxidoreductases (EC 1.1)

1.1.1: NAD/NADP acceptor	Alcohol dehydrogenase · Aldo-keto reductase (1A1, 1B1, 1B10, 1C1, 1C3, 1C4, 7A2) · Aldose reductase · Carbohydrate dehydrogenases · Carnitine dehydrogenase · DXP reductoisomerase · Glucose-6-phosphate dehydrogenase · Glycerol-3-phosphate dehydrogenase · HMG-CoA reductase · 3-Hydroxyacyl CoA dehydrogenase · Beta-hydroxybutyryl-CoA dehydrogenase · Isocitrate dehydrogenase · IMP dehydrogenase · Β-Ketoacyl ACP reductase · Lactate dehydrogenase · Malate dehydrogenase · Phosphogluconate dehydrogenase · L-threonine dehydrogenase · L-xylulose reductase · Sorbitol dehydrogenase Hydroxysteroid dehydrogenase: 3 Beta (3-beta-HSD, NSDHL) · 11 Beta (HSD11B1, HSD11B2) · 17 Beta

1.1.2: cytochrome acceptor	D-lactate dehydrogenase (cytochrome) · D-lactate dehydrogenase (cytochrome c-553) · Mannitol dehydrogenase (cytochrome)

1.1.3: oxygen acceptor	Glucose oxidase · L-gulonolactone oxidase · Xanthine oxidase

1.1.4: disulfide as acceptor	Vitamin K epoxide reductase · Vitamin-K-epoxide reductase (warfarin-insensitive)

1.1.5: quinone/similar acceptor	Quinoprotein glucose dehydrogenase

1.1.99: other acceptors	Choline dehydrogenase · L2HGDH

Metabolism: lipid metabolism · ketones/cholesterol synthesis enzymes/steroid metabolism

Mevalonate pathway

To HMG-CoA	Acetyl-Coenzyme A acetyltransferase · HMG-CoA synthase (regulated step)

Ketogenesis	HMG-CoA lyase · 3-hydroxybutyrate dehydrogenase · Thiophorase

To Mevalonic acid	HMG-CoA reductase

To DMAPP	Mevalonate kinase · Phosphomevalonate kinase · Pyrophosphomevalonate decarboxylase · Isopentenyl-diphosphate delta isomerase

Geranyl-	Dimethylallyltranstransferase · Geranyl pyrophosphate

To cholesterol

To lanosterol	Farnesyl-diphosphate farnesyltransferase · Squalene monooxygenase · Lanosterol synthase

7-Dehydrocholesterol path	Lanosterol 14α-demethylase · Sterol-C5-desaturase-like · 7-Dehydrocholesterol reductase

Desmosterol path	24-dehydrocholesterol reductase

To Bile acids

Cholesterol 7α-hydroxylase · Sterol 27-hydroxylase

aldosterone: 18-hydroxylase

cortisol/cortisone: 17α-hydroxylase · 11β dehydrogenase (HSD11B1, HSD11B2)

both: 3β dehydrogenase · 21α-hydroxylase · 11β-hydroxylase

To sex hormones

To androgens	17α-hydroxylase/17,20 lyase · 3β dehydrogenase · 17β dehydrogenase · 5α reductase

To estrogens	Aromatase

Other/ungrouped

Steroid sulfatase · Steroidogenic acute regulatory protein

see also intermediates, disorders

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