| 17β-Hydroxysteroid dehydrogenase | |||||||
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| Identifiers | |||||||
| EC number | 1.1.1.51 | ||||||
| CAS number | 9015-81-0 | ||||||
| Databases | |||||||
| IntEnz | IntEnz view | ||||||
| BRENDA | BRENDA entry | ||||||
| ExPASy | NiceZyme view | ||||||
| KEGG | KEGG entry | ||||||
| MetaCyc | metabolic pathway | ||||||
| PRIAM | profile | ||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||
| Gene Ontology | AmiGO / EGO | ||||||
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17β-Hydroxysteroid dehydrogenases (17β-HSD), also known as 17-ketosteroid oxidoreductases or simply as 17-ketosteroid reductases (17-KSR), are a group of alcohol oxidoreductases which catalyse the dehydrogenation of 17-hydroxysteroids in steroidogenesis. This includes interconversion of DHEA and androstenediol, androstenedione and testosterone, and estrone and estradiol, respectively.[1][2]
Note that the major reactions catalysed by 17β-HSD (e.g., the conversion of androstenedione to testosterone) are in fact hydrogenation (reduction) rather than dehydrogenation (oxidation) reactions.
Genes coding for 17β-HSD include:
Isozyme 3 is responsible for 17-beta-hydroxysteroid dehydrogenase deficiency.
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