2,8-Dihydroxyadenine
Oxford Dictionary of Biochemistry:
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2,8-dihydroxyadenine
an abnormal metabolite of adenine that is formed in excess by xanthine oxidase when there is a deficiency of adenine phosphoribosyltransferase. It is protein-bound in the circulation and actively secreted into the urine, where it is very insoluble and results in crystalluria and possibly calculus formation.
| 2,7-diaminofluorene, 2,5-diphenyloxazole, 2,5-bis | |
| 2-acylglycerol O-acyltransferase, 2-amino-4-methylhex-4-enoic acid, 2-arachidonylglycerol |
Wikipedia on Answers.com:
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2,8-Dihydroxyadenine
| 2,8-Dihydroxyadenine | |
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6-Amino-7,9-dihydro-1H-purine-2,8-dione
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| Identifiers | |
| CAS number | 30377-37-8 |
| PubChem | 92268 |
| ChemSpider | 83302  |
| MeSH | 2,8-dihydroxyadenine |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C5H5N5O2 |
| Molar mass | 167.126 |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
2,8-Dihydroxyadenine is a derivative of adenine which accumulates in 2,8 dihydroxy-adenine urolithiasis.
References
- Diculescu, VC; Piedade, JA; Oliveira-Brett, AM (2007). "Electrochemical behaviour of 2,8-dihydroxyadenine at a glassy carbon electrode". Bioelectrochemistry 70 (1): 141–6. doi:10.1016/j.bioelechem.2006.03.015. PMID 16713382.
- Taniguchi A, Tsuchida S, Kuno S, Mita M, Machida T, Ioritani N, Terai C, Yamanaka H, Kamatani N (2004). "Identification of two novel mutations in adenine phosphoribosyltransferase gene in patients with 2,8-dihydroxyadenine urolithiasis". Nucleosides Nucleotides Nucleic Acids 23 (8–9): 1141–5. doi:10.1081/NCN-200027393. PMID 15571218.
- Wilkinson H, Samuell C, Stower M (2004). "2,8-Dihydroxyadenine renal stones in a 41-year-old man". Ann Clin Biochem 41 (Pt 2): 160–1. doi:10.1258/000456304322880087. PMID 15025810.
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Oxford Dictionary of Biochemistry
Oxford University Press. Oxford Dictionary of Biochemistry and Molecular Biology © 1997, 2000, 2006 All rights reserved.
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