2-hydroxyphytanoyl-CoA lyase
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2-hydroxyphytanoyl-CoA lyase
| 2-hydroxyacyl-CoA lyase 1 | |
|---|---|
| Identifiers | |
| Symbol | HACL1 |
| Alt. symbols | HPCL |
| Entrez | 26061 |
| HUGO | 17856 |
| OMIM | 604300 |
| RefSeq | NM_012260 |
| UniProt | Q9UJ83 |
| Other data | |
| Locus | Chr. 3 p24.3 |
2-Hydroxyphytanoyl-CoA lyase is a peroxisomal enzyme involved in the catabolism of phytanoic acid by α-oxidation. It requires thiamine diphosphate (ThDP) as cofactor.[1]
It is classified under EC number 4.1.
References
- ^ Foulon V, Antonenkov V, Croes K et al. (1999). "Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids". Proc. Natl. Acad. Sci. U.S.A. 96 (18): 10039–44. DOI:10.1073/pnas.96.18.10039. PMC 17838. PMID 10468558. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=17838.
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