2CB-Ind
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2CB-Ind
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| Systematic (IUPAC) name | |
| (5-bromo-4,7-dimethoxy-2,3-dihydro-1H-inden-1-yl)methanamine | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | Uncontrolled |
| Routes | Oral |
| Identifiers | |
| CAS number | 912342-23-5  |
| ATC code | None |
| PubChem | CID 16086368 |
| ChemSpider | 17245022  |
| ChEMBL | CHEMBL424890 |
| Chemical data | |
| Formula | C12H16BrNO2 |
| Mol. mass | 286.164 g/mol |
| SMILES | eMolecules & PubChem |
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2CB-Ind is a conformationally-restricted derivative of the phenethylamine hallucinogen 2C-B, discovered in 2006 by a team at Purdue University. It acts as a moderately potent and selective agonist for the 5-HT2A and 5-HT2C receptors, but unlike the corresponding benzocyclobutene derivative TCB-2 which is considerably more potent than the parent compound 2C-B, 2CB-Ind is several times weaker, with racemic 2CB-Ind having a Ki of 47nM at the human 5-HT2A receptor, only slightly more potent than the mescaline analogue (R)-jimscaline.[1][2]
See also
References
- ^ McLean, TH; Parrish, JC; Braden, MR; Marona-Lewicka, D; Gallardo-Godoy, A; Nichols, DE (2006). "1-Aminomethylbenzocycloalkanes: conformationally restricted hallucinogenic phenethylamine analogues as functionally selective 5-HT2A receptor agonists". Journal of Medical Chemistry 49 (19): 5794–803. doi:10.1021/jm060656o. PMID 16970404.
- ^ Michael Robert Braden PhD. Towards a biophysical understanding of hallucinogen action. Purdue University 2007.
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