2CBFly-NBOMe
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2CBFly-NBOMe
| 2CBFly-NBOMe | |
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Other names
N-(2-Methoxybenzyl)-1-(8-bromo-2,3,6,7-tetrahydrobenzo[1,2-b:4,5-b’]difuran-4-yl)-2-aminoethane[citation needed] |
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| Identifiers | |
| Abbreviations | 2CBFly-NBOMe |
| CAS number | 1335331-42-4 |
| ChemSpider | 26234936  |
| Jmol-3D images | Image 1 Image 2 |
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| Properties | |
| Molecular formula | C20NH22O3Br |
| Molar mass | 404.298 g mol-1 |
| Exact mass | 403.078306222 g mol-1 |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
2CBFly-NBOMe (NBOMe-2C-B-FLY, Cimbi-31) is a compound indirectly derived from the phenethylamine hallucinogen 2C-B, and related to benzodifurans like 2C-B-FLY and N-benzylphenethylamines like NBOMe-2C-I. It was discovered in 2002,[1] and further researched by Ralf Heim at the Free University of Berlin,[2] and subsequently investigated in more detail by a team at Purdue University led by David Nichols.[3] It acts as a potent partial agonist for the 5HT2A serotonin receptor subtype,[4][5] with a Ki of 0.14nM at the rat 5HT2A receptor.
See also
- 2CBCB-NBOMe (NBOMe-TCB-2)
- 2C-C-NBOMe (NBOMe-2CC)
- 25B-NBOMe (NBOMe-2CB)
- 25I-NBMD (NBMD-2CI)
- 25I-NBOH (NBOH-2CI)
- 25I-NBOMe (NBOMe-2CI)
- 2C-TFM-NBOMe (NBOMe-2C-TFM)
- 25I-NBF (NBF-2CI)
References
- ^ Elz S, Kläß T, Heim R, Warnke U, Pertz HH (2002). "Development of highly potent partial agonists and chiral antagonists as tools for the study of 5-HT2A-receptor mediated function". Naunyn-Schmiedeberg's Archives of Pharmacology 365: R29.
- ^ Ralf Heim PhD. Synthese und Pharmakologie potenter 5-HT2A-Rezeptoragonisten mit N-2-Methoxybenzyl-Partialstruktur. Entwicklung eines neuen Struktur-Wirkungskonzepts. (German)
- ^ Michael Robert Braden PhD. Towards a biophysical understanding of hallucinogen action. Purdue University 2007.
- ^ Silva ME, Heim R, Strasser A, Elz S, Dove S (January 2011). "Theoretical studies on the interaction of partial agonists with the 5-HT(2A) receptor". Journal of Computer-aided Molecular Design 25 (1): 51–66. doi:10.1007/s10822-010-9400-2. PMID 21088982.
- ^ Ettrup, A.; Hansen, M.; Santini, M. A.; Paine, J.; Gillings, N.; Palner, M.; Lehel, S.; Herth, M. M. et al (2010). "Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers". European Journal of Nuclear Medicine and Molecular Imaging 38 (4): 681–693. doi:10.1007/s00259-010-1686-8. ISBN 0025901016868. PMID 21174090.
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