3-Hydroxykynurenine

3-Hydroxykynurenine
IUPAC name	2-Amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid
Identifiers
CAS number	484-78-6
PubChem	89
MeSH	3-hydroxykynurenine
SMILES	O=C(O)C(N)CC(=O)c1cccc(O)c1N
InChI	1/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)
InChI key	VCKPUUFAIGNJHC-UHFFFAOYAF
ChemSpider ID	87
Properties
Molecular formula	C10H12N2O4
Molar mass	224.21 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

3-Hydroxykynurenine is a metabolite of tryptophan.

See also

• Kynurenine
• Ommochrome

v • d • e Amino acid metabolism metabolic intermediates K→acetyl-CoA lysine→ Saccharopine · Allysine · α-Aminoadipic acid · α-Aminoadipate · Glutaryl-CoA · Glutaconyl-CoA · Crotonyl-CoA · β-Hydroxybutyryl-CoA leucine→ α-Ketoisocaproic acid · Isovaleryl-CoA · 3-Methylcrotonyl-CoA · 3-Methylglutaconyl-CoA · HMG-CoA tryptophan→alanine→ N'-Formylkynurenine · Kynurenine · Anthranilic acid · 3-Hydroxykynurenine · 3-Hydroxyanthranilic acid · 2-Amino-3-carboxymuconic semialdehyde · 2-Aminomuconic semialdehyde · 2-Aminomuconic acid · Glutaryl-CoA G G→pyruvate→citrate glycine→serine→ 3-Phosphoglyceric acid glycine→creatine: Glycocyamine · Phosphocreatine · Creatinine G→glutamate→ α-ketoglutarate histidine→ Urocanic acid · Imidazol-4-one-5-propionic acid · Formiminoglutamic acid · Glutamate-1-semialdehyde proline→ 1-Pyrroline-5-carboxylic acid arginine→ Ornithine · Putrescine · Agmatine other cysteine+glutamate→glutathione: γ-Glutamylcysteine G→propionyl-CoA→ succinyl-CoA valine→ α-Ketoisovaleric acid · Isobutyryl-CoA · Methacrylyl-CoA · 3-Hydroxyisobutyryl-CoA · 3-Hydroxyisobutyric acid · 2-Methyl-3-oxopropanoic acid isoleucine→ 2,3-Dihydroxy-3-methylpentanoic acid · 2-Methylbutyryl-CoA · Tiglyl-CoA · 2-Methylacetoacetyl-CoA methionine→ generation of homocysteine: S-Adenosyl methionine · S-Adenosyl-L-homocysteine · Homocysteine conversion to cysteine: Cystathionine · alpha-Ketobutyric acid+Cysteine threonine→ α-Ketobutyric acid propionyl-CoA→ Methylmalonyl-CoA G→fumarate phenylalanine→tyrosine→ 4-Hydroxyphenylpyruvic acid · Homogentisic acid · 4-Maleylacetoacetate G→oxaloacetate see urea cycle Other Cysteine metabolism Cysteine sulfinic acid see also enzymes, disorders

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