3F8
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| Monoclonal antibody | |
|---|---|
| Source | Mouse |
| Target | GD2 |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ? |
| Routes | intravenous |
| Identifiers | |
| ATC code | None |
| Chemical data | |
| Formula | ? |
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3F8 is a murine IgG3[1] monoclonal antibody which binds to GD2.[2]
It has been used in the detection and treatment of neuroblastoma. For imaging neuroblastoma, it is labelled with one of the radioisotopes iodine-124 and iodine-131.[3][4][5]
See also
References
- ^ Kushner BH, Cheung NK (1989). "GM-CSF enhances 3F8 monoclonal antibody-dependent cellular cytotoxicity against human melanoma and neuroblastoma". Blood 73 (7): 1936–41. PMID 2653466. http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=2653466.
- ^ "Sloan-Kettering - Neuroblastoma: 3F8 Monoclonal Antibody Therapy Q & A". http://www.mskcc.org/mskcc/html/3215.cfm#261335. Retrieved 2008-02-19.
- ^ "ACS :: New Drug Targets Tough
Childhood Cancer". http://www.cancer.org/docroot/NWS/content/NWS_1_1x_New_Drug_Targets_Tough_Childhood_Cancer.asp. Retrieved 2008-02-19.[dead link] - ^ Yeh SD, Larson SM, Burch L et al. (1991). "Radioimmunodetection of neuroblastoma with iodine-131-3F8: correlation with biopsy, iodine-131-metaiodobenzylguanidine and standard diagnostic modalities". J. Nucl. Med. 32 (5): 769–76. PMID 1902508. http://jnm.snmjournals.org/cgi/pmidlookup?view=long&pmid=1902508.
- ^ Dauer LT, St Germain J, Williamson MJ et al. (2007). "Whole-body clearance kinetics and external dosimetry of 131I-3F8 monoclonal antibody for radioimmunotherapy of neuroblastoma". Health Phys 92 (1): 33–9. doi:10.1097/01.HP.0000231583.32904.6c. PMID 17164597. http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?an=00004032-200701000-00005.
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