4-Dimethylaminophenol
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4-Dimethylaminophenol
Not to be confused with 4-Dimethylaminopyridine.
| 4-Dimethylaminophenol | |
|---|---|
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| Identifiers | |
| CAS number | 619-60-3  |
| PubChem | 22174 |
| ChemSpider | 20816 |
| UNII | X387L5559O |
| ATC code | V03 |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C8H11NO |
| Molar mass | 137.179 g/mol |
| Boiling point |
165 °C (0.040 bar) |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
4-Dimethylaminophenol (abbreviated in medical practice as DMAP) is an aromatic compound containing both phenol and amine functional groups. It has the molecular formula C8H11NO.
Uses
4-Dimethylaminophenol has been used as an antidote for cyanide poisoning.[1]
It works by generating methemoglobin. [2]
This is suitable as an emergency treatment only; treatment must be followed up with sodium thiosulfate or cobalamin.
In an animal model, it has shown effectiveness when given intramuscularly.[3]
See also
References
- ^ Kampe S, Iffland R, Korenkov M, Diefenbach C (December 2000). "Survival from a lethal blood concentration of cyanide with associated alcohol intoxication". Anaesthesia 55 (12): 1189–91. doi:10.1046/j.1365-2044.2000.01628.x. PMID 11121929. http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0003-2409&date=2000&volume=55&issue=12&spage=1189.
- ^ Vick JA, Von Bredow JD (1996). "Effectiveness of intramuscularly administered cyanide antidotes on methemoglobin formation and survival". J Appl Toxicol 16 (6): 509–16. doi:10.1002/(SICI)1099-1263(199611)16:6<509::AID-JAT382>3.0.CO;2-V. PMID 8956097.
- ^ Vick JA, Froehlich H (July 1991). "Treatment of cyanide poisoning". Mil Med 156 (7): 330–9. PMID 1922842.
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