4-Methylamphetamine
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4-Methylamphetamine
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| Systematic (IUPAC) name | |
| 1-(4-methylphenyl)propan-2-amine | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 22683-78-9  |
| ATC code | None |
| PubChem | CID 199116 |
| ChemSpider | 172349 |
| ChEMBL | CHEMBL166183 |
| Chemical data | |
| Formula | C10H15N |
| Mol. mass | 149.23 g/mol |
| SMILES | eMolecules & PubChem |
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4-Methylamphetamine (4-MA; PAL-313; Aptrol ; p-TAP) is a stimulant and anorectic drug of the phenethylamine and amphetamine chemical classes.
In vitro, it acts as a potent and balanced serotonin, norepinephrine, and dopamine releasing agent with Ki affinity values of 53.4nM, 22.2nM, and 44.1nM at the serotonin, norepinephrine, and dopamine transporters, respectively.[1] However, more recent in vivo studies that involved performing microdialysis on rats showed a different trend. These studies showed that 4-methylamphetamine is much more potent at elevating serotonin (~18 x baseline) relative to dopamine (~5 x baseline). The authors speculated that this is because 5-HT release dampens DA release through some mechanism. For example, it was suggested that a possible cause for this could be activation of 5HT2C receptors since this is known to inhibit DA release. In addition there are alternative explanations such as 5-HT release then going on to encourage GABA release, which has an inhibitory effect on DA neurons.[2]
4-MA was investigated as an appetite suppressant in 1952 and was even given a trade name, but development was apparently never completed.[3] More recently it has been reported as a novel designer drug.[4]
In animal studies, 4-MA was shown to have the lowest rate of self-administration out of a range of similar drugs tested (the others being 3-methylamphetamine, 4-fluoroamphetamine, and 3-fluoroamphetamine), likely as a result of having the highest potency for releasing serotonin relative to dopamine.[5][6]
See also
- 1-(4-Methylphenyl)-2-aminobutane
- 2-Methylamphetamine
- 3-Methylamphetamine
- 4-Methyl-N-methylamphetamine
- 4-Methyl-N-methylcathinone
- 3-Methoxy-4-methylamphetamine
- 3,4-Dimethylamphetamine
References
- ^ Wee, S.; Anderson, KG; Baumann, MH; Rothman, RB; Blough, BE; Woolverton, WL (2004). "Relationship between the Serotonergic Activity and Reinforcing Effects of a Series of Amphetamine Analogs". Journal of Pharmacology and Experimental Therapeutics 313 (2): 848–854. doi:10.1124/jpet.104.080101. PMID 15677348.
- ^ Di Giovanni, Giuseppe; Esposito, Ennio; Di Matteo, Vincenzo (2010). "Role of Serotonin in Central Dopamine Dysfunction". CNS Neuroscience & Therapeutics 16 (3): 179–194. doi:10.1111/j.1755-5949.2010.00135.x. PMID 20557570.
- ^ Gelvin, EP; McGavack, TH (1952). "2-Amino-1-(p-methylphenyl)-propane (aptrol) as an anorexigenic agent in weight reduction". New York state journal of medicine 52 (2): 223–6. PMID 14890975.
- ^ 4-Methylamphetamine alert by EMCDDA
- ^ Wee, S; Anderson, KG; Baumann, MH; Rothman, RB; Blough, BE; Woolverton, WL (2005). "Relationship between the serotonergic activity and reinforcing effects of a series of amphetamine analogs.". The Journal of Pharmacology and Experimental Therapeutics 313 (2): 848–54. doi:10.1124/jpet.104.080101. PMID 15677348.
- ^ Baumann, MH; Clark, RD; Woolverton, WL; Wee, S; Blough, BE; Rothman, RB. (Apr 2011). "In vivo effects of amphetamine analogs reveal evidence for serotonergic inhibition of mesolimbic dopamine transmission in the rat". Journal of Pharmacology and Experimental Therapeutics 337 (1): 218–25. doi:10.1124/jpet.110.176271. PMC 3063744. PMID 21228061. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3063744.
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