4-NEMD
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4-NEMD
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| Systematic (IUPAC) name | |
| 4-(1-naphthalen- 1-ylethyl)- 1H-imidazole | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 137967-81-8 |
| ATC code | ? |
| PubChem | CID 132110 |
| ChemSpider | 24531958  |
| Chemical data | |
| Formula | C15H14N2 |
| Mol. mass | 222.285 g/mol |
| SMILES | eMolecules & PubChem |
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4-NEMD is a potent sedative drug which acts as a selective alpha-2 adrenergic agonist. It is closely related to dexmedetomidine but is several times more potent.[1] Like other alpha-2 agonists, it produces sedative and muscle relaxant effects but without producing respiratory depression. It is not currently used in medicine but has been researched as the basis for a potential new generation of alpha-2 agonist drugs,[2][3] which may have selectivity for the different subtypes of the alpha-2 receptor.[4] It has two isomers, with the (S) isomer being the more potent, as with medetomidine.[5] 4-NEMD was also investigated by the United States military as an anaesthetic agent, most likely for use in surgery but possibly also for use as a non-lethal incapacitating agent.[6]
References
- ^ Hong, SS; Romstedt, KJ; Feller, DR; Hsu, FL; Cupps, TL; Lyon, RA; Miller, DD (1994). "A structure-activity relationship study of benzylic modifications of 4-1-(1-naphthyl)ethyl-1H-imidazoles on alpha 1- and alpha 2-adrenergic receptors". Journal of Medical Chemistry 37 (15): 2328–33. doi:10.1021/jm00041a011. PMID 7914537.
- ^ Zhang, X; Yao, XT; Dalton, JT; Shams, G; Lei, L; Patil, PN; Feller, DR; Hsu, FL et al (1996). "Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis, and biological activity of conformationally restricted naphthalene derivatives of medetomidine". Journal of Medical Chemistry 39 (15): 3001–13. doi:10.1021/jm9506074. PMID 8709134.
- ^ Zhang, X; De Los Angeles, JE; He, MY; Dalton, JT; Shams, G; Lei, L; Patil, PN; Feller, DR et al (1997). "Medetomidine analogs as alpha 2-adrenergic ligands. 3. Synthesis and biological evaluation of a new series of medetomidine analogs and their potential binding interactions with alpha 2-adrenoceptors involving a "methyl pocket"". Journal of Medical Chemistry 40 (19): 3014–24. doi:10.1021/jm960642q. PMID 9301663.
- ^ Lalchandani, SG; Zhang, X; Hong, SS; Liggett, SB; Li, W; Moore Bm, 2nd; Miller, DD; Feller, DR (2004). "Medetomidine analogs as selective agonists for the human alpha2-adrenoceptors". Biochemical pharmacology 67 (1): 87–96. doi:10.1016/j.bcp.2003.08.043. PMID 14667931.
- ^ Hong, SS; Romstedt, KJ; Feller, DR; Hsu, FL; George, C; Cupps, TL; Lyon, RA; Miller, DD (1992). "Resolution and adrenergic activities of the optical isomers of 4-1-(1-naphthyl)ethyl-1H-imidazole". Chirality 4 (7): 432–8. doi:10.1002/chir.530040706. PMID 1361151.
- ^ Fu-Lian Hsu and William P. Ashman. 4-(1-(1-naphthalenyl)ethyl)- 1H- imidazole, method of making and use as an anesthetic agent. US patent 5151526.
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